A Novel Inflammation-Based Stage (I Stage) Predicts Overall Survival of Patients with Nasopharyngeal Carcinoma

被引：30

作者：

Li, Jian-Pei ^{[1
]}

Chen, Shu-Lin ^{[1
]}

Liu, Xiao-Min ^{[1
]}

He, Xia ^{[1
]}

Xing, Shan ^{[1
]}

Liu, Yi-Jun ^{[1
]}

Lin, Yue-Hao ^{[1
]}

Liu, Wan-Li ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Dept Clin Lab Med, Collaborat Innovat Ctr Canc Med, Ctr Canc,State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 11期

基金：

中国国家自然科学基金;

关键词：

nasopharyngeal carcinoma; inflammation-based stage; survival; prognosis; GLASGOW-PROGNOSTIC-SCORE; REACTIVE PROTEIN/ALBUMIN RATIO; EPSTEIN-BARR-VIRUS; CANCER; SYSTEM; RESECTION; SURGERY; IMPACT;

D O I：

10.3390/ijms17111900

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies have indicated that inflammation-based prognostic scores, such as the Glasgow Prognostic Score (GPS), modified GPS (mGPS) and C-reactive protein/Albumin (CRP/Alb) ratio, platelet-lymphocyte ratio (PLR), and neutrophil-lymphocyte ratio (NLR), have been reported to have prognostic value in patients with many types of cancer, including nasopharyngeal carcinoma (NPC). In this study, we proposed a novel inflammation-based stage, named I stage, for patients with NPC. A retrospective study of 409 newly-diagnosed cases of NPC was conducted. The prognostic factors (GPS, mGPS, CRP/Alb ratios, PLR, and NLR) were evaluated using univariate and multivariate analyses. Then, according to the results of the multivariate analyses, we proposed a I stage combination of independent risk factors (CRP/Alb ratio and PLR). The I stage was calculated as follows: patients with high levels of CRP/Alb ratio (>0.03) and PLR (>146.2) were defined as I2; patients with one or no abnormal values were defined as I1 or I0, respectively. The relationships between the I stage and clinicopathological variables and overall survival (OS) were evaluated. In addition, the discriminatory ability of the I stage with other inflammation-based prognostic scores was assessed using the AUCs (areas under the curves) analyzed by receiver operating characteristics (ROC) curves. The p value of <0.05 was considered to be significant. A total of 409 patients with NPC were enrolled in this study. Multivariate analyses revealed that only the CRP/Alb ratio (Hazard ratio (HR) = 2.093; 95% Confidence interval (CI): 1.222-3.587; p = 0.007) and PLR (HR: 2.003; 95% CI: 1.177-3.410; p = 0.010) were independent prognostic factors in patients with NPC. The five-year overall survival rates for patients with I0, I1, and I2 were 92.1% +/- 2.9%, 83.3% +/- 2.6%, and 63.1% +/- 4.6%, respectively (p <0.001). The I stage had a higher area under the curve value (0.670) compared with other systemic inflammation-based prognostic scores (p <0.001). The I stage is a novel and useful predictive factor for OS in patients with NPC.

引用

页数：11