Steroidal glycosides from the underground parts of Solanum sodomaeum

被引：18
|
作者：
Ono, M
Nishimura, K
Suzuki, K
Fukushima, T
Igoshi, K
Yoshimitsu, H
Ikeda, T
Nohara, T
机构：
[1] Kyushu Tokai Univ, Sch Agr, Kumamoto 8691404, Japan
[2] Sojo Univ, Fac Pharmaceut Sci, Kumamoto 8600082, Japan
[3] Kumamoto Univ, Fac Med & Pharmaceut Sci, Kumamoto 8620973, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 02期
关键词：
Solanum sodomaeum; steroidal glycoside; solasocloside A; pregnane alkaloid; antiproliferative activity;
D O I：
10.1248/cpb.54.230
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new steroidal glycoside has been isolated from the underground parts of Solanum sodomaeum L., along with seven known steroidal glycosides. Their chemical structures were determined on the basis of spectroscopic data and chemical evidence, and the structure of one known pregnane type glycoside was corrected. In addition, their antiproliferative activity against human promyelocytic leukemia (HL-60) cells was investigated, and five compounds exhibited stronger activity than cisplatin.
引用
收藏
页码：230 / 233
页数：4
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