Intraductal papillary neoplasm of the bile duct associated with Clonorchis sinensis infection

被引：56

作者：

Jang, Kee-Taek ^{[4
]}

Hong, Seung-Mo ^{[5
]}

Lee, Kyu Taek ^{[6
]}

Lee, Jong Gyun ^{[6
]}

Choi, Seoung Ho ^{[7
]}

Heo, Jin Seok ^{[7
]}

Choi, Dong Wook ^{[7
]}

Choi, Dongil ^{[1
,2
,3
]}

Lim, Jae Hoon ^{[1
,2
,3
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Dept Radiol, Seoul 135710, South Korea

[2] Sungkyunkwan Univ, Sch Med, Ctr Imaging Sci, Samsung Med Ctr, Seoul 135710, South Korea

[3] Sungkyunkwan Univ, Sch Med, Clin Res Ctr, Samsung Biomed Res Inst, Seoul 135710, South Korea

[4] Sungkyunkwan Univ, Sch Med, Dept Pathol, Samsung Med Ctr, Seoul 135710, South Korea

[5] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

[6] Sungkyunkwan Univ, Sch Med, Dept Med, Samsung Med Ctr, Seoul 135710, South Korea

[7] Sungkyunkwan Univ, Sch Med, Dept Surg, Samsung Med Ctr, Seoul 135710, South Korea

来源：

VIRCHOWS ARCHIV | 2008年 / 453卷 / 06期

关键词：

Clonorchis sinensis; Intraductal papillary neoplasm of bile duct;

D O I：

10.1007/s00428-008-0682-x

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Intraductal papillary neoplasm of bile duct (IPNB) is one of the precursor lesions of cholangiocarcinoma. Although hepatolithiasis has been extensively studied in its association with IPNBs, there had been no comprehensive study of IPNBs with Clonorchis sinensis infection. Twelve IPNBs were selected from 20 surgically resected cholangiocarcinomas, positive for C. sinensis tests (60%) and compared with eight IPNBs, selected from 51 resected cholangiocarcinomas, negative for C. sinensis tests (16%), by histologic and immunohistochemical studies of mucin core proteins and cytokeratin panels. The predominant immuno-phenotype of IPNB cases with Clonorchiasis was pancreatobiliary type (MUC1+/MUC2-/CDX2-; 9/12 cases), while that of IPNB cases with negative for C. sinensis was intestinal type (MUC1-/MUC2+/CDX2+; 6/8; p=0.04). The prevalence of IPNBs was higher when patients with cholangiocarcinoma had Clonorchiasis. IPNBs with Clonorchiasis tended to have a more pancreatobiliary phenotype, which suggests IPNBs with Clonorchiasis may have a different tumorigenesis pathway from IPNBs with other etiologies.

引用

页码：589 / 598

页数：10

共 36 条

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