The emerging role of the interferon-induced PKR protein kinase as an apoptotic effector: A new face of death?

被引：93

作者：

Tan, SL

Katze, MG

机构：

[1] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA

[2] Univ Washington, Reg Primate Res Ctr, Seattle, WA 98195 USA

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 1999年 / 19卷 / 06期

关键词：

D O I：

10.1089/107999099313677

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent research has thrown a spotlight on the interferon (IFN)-induced PKR protein kinase, implicating it as an important effector of apoptosis induced by several cellular stress conditions, including viral infection, cytokine treatment, and growth factor deprivation. In this review, we summarize the evidence for the role of PKR as a death accomplice and discuss how PKR might promote cell demise in light of current knowledge of the molecular mechanisms of apoptosis. Given its new found role and its established antiviral function, it is no wonder that PKR is a popular target for viral evasion of the host defense. PKR-dependent apoptosis may offer a novel cell-death pathway for specific manipulation in therapeutic strategies against apoptosis-related diseases.

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收藏

页码：543 / 554

页数：12

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