Tissue-resident macrophages: from zebrafish to mouse

被引:5
作者
Lin, Xi [1 ,2 ]
Wen, Zilong [1 ,2 ]
Xu, Jin [3 ]
机构
[1] Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Div Life Sci, Kowloon, Clear Water Bay, Hong Kong, Peoples R China
[2] Hong Kong Univ Sci & Technol, Ctr Syst Biol & Human Hlth, Kowloon, Clear Water Bay, Hong Kong, Peoples R China
[3] South China Univ Technol, Sch Med, Div Cell Dev & Integrat Biol, Guangzhou, Peoples R China
来源
BLOOD SCIENCE | 2019年 / 1卷 / 01期
基金
中国国家自然科学基金;
关键词
Erythromyeloid precursor; Hematopoiesis; Hematopoietic stem cell; Metaphocyte; Mouse; Tissue-resident macrophage; Zebrafish;
D O I
10.1097/BS9.0000000000000013
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Tissue-resident macrophages (TRMs), generally found in tissues under normal physiological conditions, play crucial roles not only in immunity but also in tissue development and homeostasis. Because of their diverse functions, dysregulation of their development and function has been implicated in many human disorders. In the past decade, a great deal of extensive studies have been conducted in various model organisms with cutting-edge technologies to explore the origin and function of TRMs. In this review, we summarize the recent findings on TRMs in mouse and zebrafish and compare the similarity/differences between these two species.
引用
收藏
页码:57 / 60
页数:4
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