Validation of the Angioedema Control Test (AECT)-A Patient-Reported Outcome Instrument for Assessing Angioedema Control

被引：72

作者：

Weller, Karsten ^{[1
]}

Donoso, Tamara ^{[1
]}

Magerl, Markus ^{[1
]}

Aygoeren-Puersuen, Emel ^{[2
]}

Staubach, Petra ^{[3
]}

Martinez-Saguer, Inmaculada ^{[4
]}

Hawro, Tomasz ^{[1
]}

Altrichter, Sabine ^{[1
]}

Krause, Karoline ^{[1
]}

Siebenhaar, Frank ^{[1
]}

Metz, Martin ^{[1
]}

Zuberbier, Torsten ^{[1
]}

Freier, Denise ^{[1
]}

Maurer, Marcus ^{[1
]}

机构：

[1] Charite Univ Med Berlin, Allergie Ctr Charite, Dept Dermatol & Allergy, Dermatol Allergol, Berlin, Germany

[2] Goethe Univ, Univ Hosp Frankfurt, Dept Children & Adolescents, Frankfurt, Germany

[3] Univ Med Ctr Mainz, Dept Dermatol, Mainz, Germany

[4] HRZM Hemophilia Ctr Rhein Main, Morfelden Walldorf, Germany

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2020年 / 8卷 / 06期

关键词：

Angioedema; Control test; Cutoff; Development; Disease control; Patient-reported outcome; Reliability; Screening; Validation; Validity; QUALITY-OF-LIFE; URTICARIA CONTROL; OMALIZUMAB; BURDEN;

D O I：

10.1016/j.jaip.2020.02.038

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

BACKGROUND: Recurrent angioedema (RA) is an important clinical problem in routine care and emergency medicine. As of recently, the only validated tools to specifically assess disease status in patients with RA were diary-type activity assessments and angioedema-related quality-of-life questionnaires. Although these tools are particularly helpful in clinical studies, they were not designed to determine disease control or to guide treatment decisions. To close this gap, the Angioedema Control Test (AECT) was published recently. OBJECTIVE: To test the AECT for its validity and reliability, and to identify a cutoff value to aid treatment decisions. METHODS: Two AECT versions with a recall period of 4 weeks (AECT-4wk) and 3 months (AECT-3mo) were tested for their internal consistency and test-retest reliability, convergent and known-groups validity as well as screening accuracy in 81 patients with RA with bradykinin-mediated angioedema, mast cell mediator-mediated angioedema, or idiopathic angioedema. RESULTS: Both AECT versions showed excellent internal consistency reliability with a Cronbach alpha value of more than 0.85 and test-retest reliability with an intraclass correlation co-efficient greater than 0.9. The convergent validity of both AECT versions was high. Both tools showed strong correlations with anchors of disease control, angioedema frequency, and health -related quality of life. A stratification of AECT scores into different levels of disease control together with a receiver -operating characteristic curve analysis suggested a cutoff value of 10 or more points to identify patients with well-controlled RA versus less than 10 points to identify patients with poorly controlled disease for both AECT versions. CONCLUSIONS: The AECT is the first valid and reliable patient-reported outcome measure to assess disease control in patients with RA. (c) 2020 American Academy of Allergy, Asthma & Immunology

引用

页码：2050 / +

页数：12

共 27 条

[1] Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema [J].

Aygoeren-Puersuen, E. ;

Bygum, A. ;

Grivcheva-Panovska, V. ;

Magerl, M. ;

Graff, J. ;

Steiner, U. C. ;

Fain, O. ;

Huissoon, A. ;

Kinaciyan, T. ;

Farkas, H. ;

Lleonart, R. ;

Longhurst, H. J. ;

Rae, W. ;

Triggiani, M. ;

Aberer, W. ;

Cancian, M. ;

Zanichelli, A. ;

Smith, W. B. ;

Baeza, M. L. ;

Du-Thanh, A. ;

Gompels, M. ;

Gonzalez-Quevedo, T. ;

Greve, J. ;

Guilarte, M. ;

Katelaris, C. ;

Dobo, S. ;

Cornpropst, M. ;

Clemons, D. ;

Fang, L. ;

Collis, P. ;

Sheridan, W. ;

Maurer, M. ;

Cicardi, M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (04) :352-362

[2] Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of epidemiological studies [J].

Aygoeren-Puersuen, Emel ;

Magerl, Markus ;

Maetzel, Andreas ;

Maurer, Marcus .

ORPHANET JOURNAL OF RARE DISEASES, 2018, 13

[3] Effect of Lanadelumab Compared With Placebo on Prevention of Hereditary Angioedema Attacks A Randomized Clinical Trial [J].

Banerji, Aleena ;

Riedl, Marc A. ;

Bernstein, Jonathan A. ;

Cicardi, Marco ;

Longhurst, Hilary J. ;

Zuraw, Bruce L. ;

Busse, Paula J. ;

Anderson, John ;

Magerl, Markus ;

Martinez-Saguer, Inmaculada ;

Davis-Lorton, Mark ;

Zanichelli, Andrea ;

Li, H. Henry ;

Craig, Timothy ;

Jacobs, Joshua ;

Johnston, Douglas T. ;

Shapiro, Ralph ;

Yang, William H. ;

Lumry, William R. ;

Manning, Michael E. ;

Schwartz, Lawrence B. ;

Shennak, Mustafa ;

Soteres, Daniel ;

Zaragoza-Urdaz, Rafael H. ;

Gierer, Selina ;

Smith, Andrew M. ;

Tachdjian, Raffi ;

JamesWedner, H. ;

Hebert, Jacques ;

Rehman, Syed M. ;

Staubach, Petra ;

Schranz, Jennifer ;

Baptista, Jovanna ;

Nothaft, Wolfram ;

Maurer, Marcus .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2018, 320 (20) :2108-2121

[4] The burden of illness in patients with hereditary angioedema [J].

Banerji, Aleena .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2013, 111 (05) :329-336

[5] Disease Severity, Activity, Impact, and Control and How to Assess Them in Patients with Hereditary Angioedema. [J].

Bygum, Anette ;

Busse, Paula ;

Caballero, Teresa ;

Maurer, Marcus .

FRONTIERS IN MEDICINE, 2017, 4

[6] DERMATOLOGY LIFE QUALITY INDEX (DLQI) - A SIMPLE PRACTICAL MEASURE FOR ROUTINE CLINICAL USE [J].

FINLAY, AY ;

KHAN, GK .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 1994, 19 (03) :210-216

[7] Cross-validation of item selection and scoring for the SF-12 Health Survey in nine countries: Results from the IQOLA Project [J].

Gandek, B ;

Ware, JE ;

Aaronson, NK ;

Apolone, G ;

Bjorner, JB ;

Brazier, JE ;

Bullinger, M ;

Kaasa, S ;

Leplege, A ;

Prieto, L ;

Sullivan, M .

JOURNAL OF CLINICAL EPIDEMIOLOGY, 1998, 51 (11) :1171-1178

[8] Translating the science of quality of life into practice: What do dermatology life quality index scores mean? [J].

Hongbo, Y ;

Thomas, CL ;

Harrison, MA ;

Salek, MS ;

Finlay, AY .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2005, 125 (04) :659-664

[9] Validation of the Turkish version of the Urticaria Control Test: Correlation with other tools and comparison between spontaneous and inducible chronic urticaria [J].

Kocaturk, Emek ;

Kiziltac, Utkan ;

Can, Pelin ;

Kara, Oztas ;

Erdem, Teoman ;

Kiziltac, Kubra ;

Sahillioglu, Nagihan ;

Gelincik, Asli ;

Maurer, Marcus ;

Weller, Karsten .

WORLD ALLERGY ORGANIZATION JOURNAL, 2019, 12 (01)

[10] New treatments for chronic urticaria [J].

Kolkhir, Pavel ;

Altrichter, Sabine ;

Munoz, Melba ;

Hawro, Tomasz ;

Maurer, Marcus .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2020, 124 (01) :2-12

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