microRNA Biogenesis Pathway as a Therapeutic Target for Human Disease and Cancer

被引：35
作者：
De Santa, Francesca [1 ,4 ]
Iosue, Ilaria [2 ]
Del Rio, Alberto [3 ]
Fazi, Francesco [1 ]
机构：
[1] Univ Roma La Sapienza, Dept Med Surg Sci & Biotechnol, I-04100 Latina, Italy
[2] Univ Roma La Sapienza, DAHFMO, Sect Histol & Med Embryol, I-00161 Rome, Italy
[3] Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy
[4] CNR, Inst Cellular Biol & Neurobiol, I-00143 Rome, Italy
来源：
CURRENT PHARMACEUTICAL DESIGN | 2013年 / 19卷 / 04期
关键词：
microRNA; drosha; exportin-5; dicer; argonaute proteins; RNA-based drugs and therapies; small molecules design; crystallography; NMR; TUMOR-SUPPRESSOR MICRORNA; RNA-BINDING PROTEINS; CHRONIC LYMPHOCYTIC-LEUKEMIA; A-AEOLICUS ARGONAUTE; HUMAN LUNG CANCERS; CRYSTAL-STRUCTURE; LET-7; MICRORNA; IN-VIVO; CELL-PROLIFERATION; SILENCING COMPLEX;
D O I：
10.2174/138161213804581846
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The deregulation of microRNAs expression and activity is frequently observed in a wide variety of human pathologies including cancer. Accordingly, growing evidence indicates that the targeting of microRNAs biogenesis and pathways is emerging as a central tool for the development of novel RNA-based drugs and therapies to defeat diseases in humans. In this review we describe the various strategies that can be used to target microRNAs and specific RNA-binding proteins, involved in the regulation of their production, localization, stability and activity, in human cancer and cardiovascular diseases. We also focus on the efforts that are currently made to enhance the potency and stability of these therapeutic agents and their delivery to modulate in vivo microRNAs pathways. Finally, we present structural data on proteins that belong to the microRNA pathway for small molecules-based target therapy design.
引用
收藏
页码：745 / 764
页数：20
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