The effect of various disease-modifying anti-rheumatic drugs on the suppressive function of CD4+CD25+ regulatory T cells

被引：25

作者：

Oh, Ji Seon ^{[1
]}

Kim, Yong-Gil ^{[2
]}

Lee, Seung Geun ^{[3
]}

So, Min Wook ^{[2
]}

Choi, Seung Won ^{[1
]}

Lee, Chang-Keun ^{[2
]}

Yoo, Bin ^{[2
]}

机构：

[1] Univ Ulsan, Div Rheumatol, Dept Internal Med, Coll Med,Ulsan Univ Hosp, Ulsan 682714, South Korea

[2] Univ Ulsan, Div Rheumatol, Dept Internal Med, Asan Med Ctr,Coll Med, Seoul 138736, South Korea

[3] Inje Univ, Div Rheumatol, Dept Internal Med, Haeundae Paik Hosp, Pusan, South Korea

来源：

RHEUMATOLOGY INTERNATIONAL | 2013年 / 33卷 / 02期

关键词：

Regulatory T-lymphocytes; Rheumatoid arthritis; Antirheumatic agents; Methotrexate; Sulfasalazine; Leflunomide; Infliximab; IMMUNOLOGICAL SELF-TOLERANCE; REMITTING MULTIPLE-SCLEROSIS; EARLY RHEUMATOID-ARTHRITIS; PERIPHERAL-BLOOD; IN-VITRO; INTERLEUKIN-2; PRODUCTION; CALCINEURIN INHIBITORS; TRANSPLANT RECIPIENTS; INDUCED EXACERBATION; ULCERATIVE-COLITIS;

D O I：

10.1007/s00296-012-2365-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Accumulating evidence suggests that defects in the function of CD4(+)CD25(+) regulatory T cells (Tregs) are important in immune-mediated diseases such as rheumatoid arthritis. Here, we investigated the effects of various disease-modifying anti-rheumatic drugs (DMARDs) on Treg function. Tregs and CD4(+)CD25(-) effector T cells (Teffs) were isolated from peripheral blood mononuclear cells obtained from healthy adults. Isolated Tregs were cultured with the DMARDs methotrexate (MTX), sulfasalazine (SSZ), leflunomide (LEF), or infliximab (INF). We found that each DMARD had a different effect on Treg function. SSZ and LEF inhibited the anti-proliferative function of Tregs on cocultured Teffs and reduced Treg expression of Foxp3 mRNA, whereas MTX and INF did not.

引用

页码：381 / 388

页数：8

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