Polycystic ovary syndrome: evidence for a primary disorder of ovarian steroidogenesis

被引：17

作者：

Franks, S ^{[1
]}

Gharani, N ^{[1
]}

Gilling-Smith, C ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, St Marys Hosp, Sch Med, Dept Reprod Sci & Med, London W2 1PG, England

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1999年 / 69卷 / 1-6期

关键词：

D O I：

10.1016/S0960-0760(99)00044-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polycystic ovary syndrome (PCOS) is a very common endocrinopathy of uncertain aetiology in which the most consistent biochemical abnormality is hypersecretion of androgens. In this review, evidence is presented to support the view that a primary abnormality of ovarian androgen biosynthesis provides the basis for the syndrome. PCOS is a familiar disorder and we demonstrate, in molecular genetic studies, that CYP11a, the gene coding for P450 side chain cleavage, is a key susceptibility locus for development of hyperandrogenism. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

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收藏

页码：269 / 272

页数：4

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