Serum levels of arginase I are associated with left ventricular function after myocardial infarction

被引:21
作者
Bekpinar, Seldag [1 ]
Gurdol, Figen [1 ]
Unlucerci, Yesim [1 ]
Develi, Seval [1 ]
Yilmaz, Akar [2 ]
机构
[1] Istanbul Univ, Dept Biochem, Istanbul Fac Med, TR-34093 Istanbul, Turkey
[2] Istanbul Univ, Dept Cardiol, Istanbul Fac Med, TR-34093 Istanbul, Turkey
关键词
Arginase; Myocardial infarction; Ventricular dysfunction; Diabetes mellitus;
D O I
10.1016/j.clinbiochem.2011.06.003
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Objectives: Upregulation of arginase redirects the arginine metabolism from nitric oxide (NO) synthesis to the formation of polyamine and proline, thus causing cardiac dysfunction. NO synthesis is also impaired by asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor. We aimed to evaluate the impact of arginase and ADMA levels on left ventricular function after myocardial infarction (MI). Design and methods: Blood samples from 43 MI patients and 33 controls were used. Arginase I and TNF-alpha were quantified by ELISA; arginine, ADMA and homocysteine concentrations by HPLC; and high-sensitive CRP by immunoassay techniques. Results: Arginase concentrations were higher in MI patients than in controls (121 +/- 73 ng/mL vs 58 +/- 41, p=0.001) and were negatively associated with left ventricular ejection fraction (r=-0.467, p=0.019). Significantly low arginine/ADMA ratio was observed in MI patients. Conclusion: Induced arginase I after myocardial infarction may deplete the arginine pool. The changes related to arginine metabolism may have a role in ventricular dysfunction. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:1090 / 1093
页数:4
相关论文
共 30 条
[1]   Arginase pathway in human endothelial cells in pathophysiological conditions [J].
Bachetti, T ;
Comini, L ;
Francolini, G ;
Bastianon, D ;
Valetti, B ;
Cadei, M ;
Grigolato, PG ;
Suzuki, H ;
Finazzi, D ;
Albertini, A ;
Curello, S ;
Ferrari, R .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2004, 37 (02) :515-523
[2]   Plasma Asymmetric Dimethylarginine and Incidence of Cardiovascular Disease and Death in the Community [J].
Boeger, Rainer H. ;
Sullivan, Lisa M. ;
Schwedhelm, Edzard ;
Wang, Thomas J. ;
Maas, Renke ;
Benjamin, Emelia J. ;
Schulze, Friedrich ;
Xanthakis, Vanessa ;
Benndorf, Ralf A. ;
Vasan, Ramachandran S. .
CIRCULATION, 2009, 119 (12) :1592-U65
[3]   Homocysteine lowering and cardiovascular events after acute myocardial infarction [J].
Bonaa, KH ;
Njolstad, I ;
Ueland, PM ;
Schirmer, H ;
Tverdal, A ;
Steigen, T ;
Wang, H ;
Nordrehaug, JE ;
Arnesen, E ;
Rasmussen, K .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (15) :1578-1588
[4]   Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study [J].
Booth, Gillian L. ;
Kapral, Moira K. ;
Fung, Kinwah ;
Tu, Jack V. .
LANCET, 2006, 368 (9529) :29-36
[5]   Relation of baseline plasma ADMA levels to cardiovascular morbidity and mortality at two years in men with diabetes mellitus referred for coronary angiography [J].
Cavusoglu, Erdal ;
Ruwende, Cyril ;
Chopra, Vineet ;
Poludasu, Shyam ;
Yanamadala, Sunitha ;
Frishman, William H. ;
Eng, Calvin ;
Pinsky, David J. ;
Marmur, Jonathan D. .
ATHEROSCLEROSIS, 2010, 210 (01) :226-231
[6]   Homocyst(e)ine: An important risk factor for atherosclerotic vascular disease [J].
Duell, PB ;
Malinow, MR .
CURRENT OPINION IN LIPIDOLOGY, 1997, 8 (01) :28-34
[7]   Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima-media thickness [J].
Dumont, Julie ;
Zureik, Mahmoud ;
Cottel, Dominique ;
Montaye, Michele ;
Ducimetiere, Pierre ;
Amouyel, Philippe ;
Brousseau, Thierry .
JOURNAL OF MEDICAL GENETICS, 2007, 44 (08) :526-531
[8]   Transforming growth factor-β1 stimulates L-arginine transport and metabolism in vascular smooth muscle cells -: Role in polyamine and collagen synthesis [J].
Durante, W ;
Liao, L ;
Reyna, SV ;
Peyton, KJ ;
Schafer, AI .
CIRCULATION, 2001, 103 (08) :1121-1127
[9]   Prognostic value of systemic endothelial dysfunction in patients with acute coronary syndromes - Further evidence for the existence of the "vulnerable" patient [J].
Fichtlscherer, S ;
Breuer, S ;
Zeiher, AM .
CIRCULATION, 2004, 110 (14) :1926-1932
[10]   Monocyte and macrophage heterogeneity [J].
Gordon, S ;
Taylor, PR .
NATURE REVIEWS IMMUNOLOGY, 2005, 5 (12) :953-964