Synthesis of pyrazolines, isoxazolines and aminopyrimidines as biological potent agents

Chalcones, 2-phenylamino-4-(4'-fluorophenylamino)-6-[4'-{3 ''-(phenyl/substituted phenyl /2"'-furanyl/3"'-pyidinyl)-2"-propenon- 1 ''-y1} phenylamino]-s-triazines 6a-j have been prepared from ketone 5 based oil s-triazine nucleus. These chalcones 6a-j oil cyclisation with hydrazine hydrate, hydroxylamine hydrochloride and guanidine nitrate give the corresponding pyrazolines 7a-j, isoxazolines 8a-j and aminopyrimidines 9a-j, respectively. Antimicrobial activities of all synthesized compounds have been performed by using cup-plate method against bacteria and by using poisoned food technique against fungi. The constitutions of newly synthesized compounds have been established on the basis of elemental analysis, IR and H-I NMR spectral data.