Interleukin-6-174-genotype, sepsis and cerebral injury in very low birth weight infants

被引:39
作者
Göpel, W
Härtel, C
Ahrens, P
König, I
Kattner, E
Kuhls, E
Küster, H
Möller, J
Müller, D
Roth, B
Segerer, H
Wieg, C
Herting, E
机构
[1] Univ Lubeck, Dept Pediat, D-23538 Lubeck, Germany
[2] Univ Lubeck, Inst Med Biometry & Stat, D-23538 Lubeck, Germany
[3] Kinderklin Bult, Hannover, Germany
[4] Olga Hosp, Stuttgart, Germany
[5] Univ Greifswald, Dept Pediat, Greifswald, Germany
[6] Childrens Hosp, Kassel, Germany
[7] Childrens Hosp, Saarbrucken, Germany
[8] Univ Cologne, Dept Neonatol, Cologne, Germany
[9] Kinderklin St Hedwig, Regensburg, Germany
[10] Childrens Hosp, Aschaffenburg, Germany
关键词
preterm infants; interleukin; 6; intraventricular hemorrhage; sepsis;
D O I
10.1038/sj.gene.6364264
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
We investigated the association between the interleukin 6 (IL-6)-174-genotype and unfavorable outcomes in preterm infants since it has been reported that the IL-6-174GG-genotype is associated with increased susceptibility to sepsis, and the IL-6174CC- genotype is more common in preterm infants with severe intraventricular hemorrhage (IVH). We studied 1206 preterm infants with a birth weight below 1500 g. In contrast to previously published data, the frequency of IVH grade IV, periventricular leukomalacia, ventricular-peritoneal-shunting or death was not different between infants with different IL-6-genotypes: IL-6174GG (n = 430) 8%, IL-6-174GC ( n = 605) 9% and IL-6-174CC ( n = 167) 12% ( P = 0.2 for IL-6-174CC vs GG+GC). Furthermore, we were not able to confirm previously reported association between sepsis and the IL-6-174GG-genotype. Blood-culture-proven sepsis occurred in 19% of IL-6-174GG-carriers ( n = 157), 26% of IL-6-174GC-carriers ( n = 193) and 27% of infants carrying the IL-6-174CC- genotype ( n 67). We were not able to confirm previously reported associations between sepsis, cerebral injury and the IL-6-174-genotype in VLBW-infants.
引用
收藏
页码:65 / 68
页数:4
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