CD4+ T-Lymphocyte Count/CD8+ T-Lymphocyte Count Ratio: Surrogate for HIV Infection in Infants?

被引：0

作者：

Navaneethapandian, Poorana Ganga Devi ^{[1
]}

Karunaianantham, Ramesh ^{[1
]}

Subramanyan, Sudha ^{[1
]}

Chinnayan, Ponnuraja ^{[1
]}

Chandrasekaran, Padmapriyadarsini ^{[1
]}

Swaminathan, Soumya ^{[1
]}

机构：

[1] Indian Council Med Res, Natl Inst Res TB, Madras 600031, Tamil Nadu, India

来源：

JOURNAL OF TROPICAL PEDIATRICS | 2012年 / 58卷 / 05期

关键词：

HIV; infants; surrogate marker; CD4; CD8; ratio; diagnosis; CELL RATIO; MORTALITY; DIAGNOSIS;

D O I：

10.1093/tropej/fmr102

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Methods: Two hundred and fifty-eight HIV-exposed Indian infants at a median age of 5 months (range 1-18) had DNA PCR and CD4, CD8 counts performed. Results: Fifty five infants tested positive by HIV-1 DNA PCR whereas 203 were negative. Median CD4 count, CD4% and CD4/CD8 ratio were significantly lower in DNA PCR+ infants. Overall sensitivity and specificity of CD4/CD8 ratio < 1.0 in predicting HIV was 91 and 92% with a negative predicted value (NPV) and positive predicted value (PPV) of 97 and 76%, respectively. Conclusion: CD4/CD8 ratio < 1.0 is a more sensitive surrogate marker of HIV infection in Indian infants than a CD4 count < 1500 cells/mu l or CD4% < 25%.

引用

页码：394 / 397

页数：4

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