CD4+ T-Lymphocyte Count/CD8+ T-Lymphocyte Count Ratio: Surrogate for HIV Infection in Infants?

被引：0
作者：
Navaneethapandian, Poorana Ganga Devi [1 ]
Karunaianantham, Ramesh [1 ]
Subramanyan, Sudha [1 ]
Chinnayan, Ponnuraja [1 ]
Chandrasekaran, Padmapriyadarsini [1 ]
Swaminathan, Soumya [1 ]
机构：
[1] Indian Council Med Res, Natl Inst Res TB, Madras 600031, Tamil Nadu, India
来源：
JOURNAL OF TROPICAL PEDIATRICS | 2012年 / 58卷 / 05期
关键词：
HIV; infants; surrogate marker; CD4; CD8; ratio; diagnosis; CELL RATIO; MORTALITY; DIAGNOSIS;
D O I：
10.1093/tropej/fmr102
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Methods: Two hundred and fifty-eight HIV-exposed Indian infants at a median age of 5 months (range 1-18) had DNA PCR and CD4, CD8 counts performed. Results: Fifty five infants tested positive by HIV-1 DNA PCR whereas 203 were negative. Median CD4 count, CD4% and CD4/CD8 ratio were significantly lower in DNA PCR+ infants. Overall sensitivity and specificity of CD4/CD8 ratio < 1.0 in predicting HIV was 91 and 92% with a negative predicted value (NPV) and positive predicted value (PPV) of 97 and 76%, respectively. Conclusion: CD4/CD8 ratio < 1.0 is a more sensitive surrogate marker of HIV infection in Indian infants than a CD4 count < 1500 cells/mu l or CD4% < 25%.
引用
收藏
页码：394 / 397
页数：4
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