Pushing the limits of targeted therapy in chronic myeloid leukaemia

被引：250

作者：

O'Hare, Thomas ^{[1
]}

Zabriskie, Matthew S. ^{[1
]}

Eiring, Anna M. ^{[1
]}

Deininger, Michael W. ^{[1
]}

机构：

[1] Univ Utah, Div Hematol & Hematol Malignancies, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 08期

关键词：

CHRONIC MYELOGENOUS LEUKEMIA; KINASE DOMAIN MUTATIONS; DIAGNOSED CHRONIC-PHASE; BCR-ABL1; LYMPHOBLASTIC-LEUKEMIA; COMPLETE MOLECULAR REMISSION; PATIENTS RECEIVING IMATINIB; CHROMOSOME-POSITIVE CELLS; BCR-ABL INHIBITORS; STEM-CELLS; TYROSINE KINASE;

D O I：

10.1038/nrc3317

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tyrosine kinase inhibitor (TKI) therapy targeting the BCR-ABL1 kinase is effective against chronic myeloid leukaemia (CML), but is not curative for most patients. Minimal residual disease (MRD) is thought to reside in TKI-insensitive leukaemia stem cells (LSCs) that are not fully addicted to BCR-ABL1. Recent conceptual advances in both CML biology and therapeutic intervention have increased the potential for the elimination of CML cells, including LSCs, through simultaneous inhibition of BCR-ABL1 and other newly identified, crucial targets.

引用

页码：513 / 526

页数：14

共 167 条

[41] The ABL Switch Control Inhibitor DCC-2036 Is Active against the Chronic Myeloid Leukemia Mutant BCR-ABLT315I and Exhibits a Narrow Resistance Profile [J].

Eide, Christopher A. ;

Adrian, Lauren T. ;

Tyner, Jeffrey W. ;

Mac Partlin, Mary ;

Anderson, David J. ;

Wise, Scott C. ;

Smith, Bryan D. ;

Petillo, Peter A. ;

Flynn, Daniel L. ;

Deininger, Michael W. N. ;

O'Hare, Thomas ;

Druker, Brian J. .

CANCER RESEARCH, 2011, 71 (09) :3189-3195

[42] miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts [J].

Eiring, Anna M. ;

Harb, Jason G. ;

Neviani, Paolo ;

Garton, Christopher ;

Oaks, Joshua J. ;

Spizzo, Riccardo ;

Liu, Shujun ;

Schwind, Sebastian ;

Santhanam, Ramasamy ;

Hickey, Christopher J. ;

Becker, Heiko ;

Chandler, Jason C. ;

Andino, Raul ;

Cortes, Jorge ;

Hokland, Peter ;

Huettner, Claudia S. ;

Bhatia, Ravi ;

Roy, Denis C. ;

Liebhaber, Stephen A. ;

Caligiuri, Michael A. ;

Marcucci, Guido ;

Garzon, Ramiro ;

Croce, Carlo M. ;

Calin, George A. ;

Perrotti, Danilo .

CELL, 2010, 140 (05) :652-665

[43] SHP-1 expression accounts for resistance to imatinib treatment in Philadelphia chromosome-positive cells derived from patients with chronic myeloid leukemia [J].

Esposito, Nicola ;

Colavita, Irene ;

Quintarelli, Concetta ;

Sica, Agostino Rodeo ;

Peluso, Anna Lucia ;

Luciano, Luigia ;

Picardi, Marco ;

Del Vecchio, Luigi ;

Buonomo, Tonia ;

Hughes, Timothy P. ;

White, Deborah ;

Radich, Jerald P. ;

Russo, Domenico ;

Branford, Susan ;

Saglio, Giuseppe ;

Melo, Junia V. ;

Martinelli, Rosanna ;

Ruoppolo, Margherita ;

Kalebic, Thea ;

Martinelli, Giovanni ;

Pane, Fabrizio .

BLOOD, 2011, 118 (13) :3634-3644

[44] Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells [J].

Essafi, A ;

de Mattos, SF ;

Hassen, YAM ;

Soeiro, I ;

Mufti, GJ ;

Thomas, NSB ;

Medema, RH ;

Lam, EWF .

ONCOGENE, 2005, 24 (14) :2317-2329

[45] Development of resistance to dasatinib in Bcr/Abl-positive acute lymphoblastic leukemia [J].

Fei, F. ;

Stoddart, S. ;

Mueschen, M. ;

Kim, Y-M ;

Groffen, J. ;

Heisterkamp, N. .

LEUKEMIA, 2010, 24 (04) :813-820

[46] How I treat Philadelphia chromosome-positive acute lymphoblastic leukemia [J].

Fielding, Adele K. .

BLOOD, 2010, 116 (18) :3409-3417

[47] Dasatinib as first-line treatment for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia [J].

Foa, Robin ;

Vitale, Antonella ;

Vignetti, Marco ;

Meloni, Giovanna ;

Guarini, Anna ;

De Propris, Maria Stefania ;

Elia, Loredana ;

Paoloni, Francesca ;

Fazi, Paola ;

Cimino, Giuseppe ;

Nobile, Francesco ;

Ferrara, Felicetto ;

Castagnola, Carlo ;

Sica, Simona ;

Leoni, Pietro ;

Zuffa, Eliana ;

Fozza, Claudio ;

Luppi, Mario ;

Candoni, Anna ;

Iacobucci, Ilaria ;

Soverini, Simona ;

Mandelli, Franco ;

Martinelli, Giovanni ;

Baccarani, Michele .

BLOOD, 2011, 118 (25) :6521-6528

[48] Multicenter Independent Assessment of Outcomes in Chronic Myeloid Leukemia Patients Treated With Imatinib [J].

Gambacorti-Passerini, Carlo ;

Antolini, Laura ;

Mahon, Francois-Xavier ;

Guilhot, Francois ;

Deininger, Michael ;

Fava, Carmen ;

Nagler, Arnon ;

Della Casa, Chiara Maria ;

Morra, Enrica ;

Abruzzese, Elisabetta ;

D'Emilio, Anna ;

Stagno, Fabio ;

le Coutre, Philipp ;

Hurtado-Monroy, Rafael ;

Santini, Valeria ;

Martino, Bruno ;

Pane, Fabrizio ;

Piccin, Andrea ;

Giraldo, Pilar ;

Assouline, Sarit ;

Durosinmi, Muheez A. ;

Leeksma, Onno ;

Pogliani, Enrico Maria ;

Puttini, Miriam ;

Jang, Eunjung ;

Reiffers, Josy ;

Valsecchi, Maria Grazia ;

Kim, Dong-Wook .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2011, 103 (07) :553-561

[49] Hedgehog Signaling Is Dispensable for Adult Hematopoietic Stem Cell Function [J].

Gao, Jie ;

Graves, Stephanie ;

Koch, Ute ;

Liu, Suqing ;

Jankovic, Vladimir ;

Buonamici, Silvia ;

El Andaloussi, Abdeljabar ;

Nimer, Stephen D. ;

Kee, Barbara L. ;

Taichman, Russell ;

Radtke, Freddy ;

Aifantis, Iannis .

CELL STEM CELL, 2009, 4 (06) :548-558

[50] The use of nilotinib or dasatinib after failure to 2 prior tyrosine kinase inhibitors: long-term follow-up [J].

Garg, Ravin J. ;

Kantarjian, Hagop ;

O'Brien, Susan ;

Quintas-Cardama, Alfonso ;

Faderl, Stefan ;

Estrov, Zeev ;

Cortes, Jorge .

BLOOD, 2009, 114 (20) :4361-4368

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