Pushing the limits of targeted therapy in chronic myeloid leukaemia

被引：250

作者：

O'Hare, Thomas ^{[1
]}

Zabriskie, Matthew S. ^{[1
]}

Eiring, Anna M. ^{[1
]}

Deininger, Michael W. ^{[1
]}

机构：

[1] Univ Utah, Div Hematol & Hematol Malignancies, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 08期

关键词：

CHRONIC MYELOGENOUS LEUKEMIA; KINASE DOMAIN MUTATIONS; DIAGNOSED CHRONIC-PHASE; BCR-ABL1; LYMPHOBLASTIC-LEUKEMIA; COMPLETE MOLECULAR REMISSION; PATIENTS RECEIVING IMATINIB; CHROMOSOME-POSITIVE CELLS; BCR-ABL INHIBITORS; STEM-CELLS; TYROSINE KINASE;

D O I：

10.1038/nrc3317

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tyrosine kinase inhibitor (TKI) therapy targeting the BCR-ABL1 kinase is effective against chronic myeloid leukaemia (CML), but is not curative for most patients. Minimal residual disease (MRD) is thought to reside in TKI-insensitive leukaemia stem cells (LSCs) that are not fully addicted to BCR-ABL1. Recent conceptual advances in both CML biology and therapeutic intervention have increased the potential for the elimination of CML cells, including LSCs, through simultaneous inhibition of BCR-ABL1 and other newly identified, crucial targets.

引用

页码：513 / 526

页数：14

共 167 条

[31] Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib [J].

Cortes, Jorge E. ;

Kantarjian, Hagop M. ;

Bruemmendorf, Tim H. ;

Kim, Dong-Wook ;

Turkina, Anna G. ;

Shen, Zhi-Xiang ;

Pasquini, Ricardo ;

Khoury, H. Jean ;

Arkin, Steven ;

Volkert, Angela ;

Besson, Nadine ;

Abbas, Richat ;

Wang, Junyuan ;

Leip, Eric ;

Gambacorti-Passerini, Carlo .

BLOOD, 2011, 118 (17) :4567-4576

[32]

Deininger M, 2009, BLOOD, V114

[33] Expansion of Bcr-Abl-positive leukemic stem cells is dependent on hedgehog pathway activation [J].

Dierks, Christine ;

Beigi, Ronak ;

Guo, Gui-Rong ;

Zirlik, Katja ;

Stegert, Mario R. ;

Manley, Paul ;

Trussell, Christopher ;

Schmitt-Graeff, Annette ;

Landwerlin, Klemens ;

Veelken, Hendrik ;

Warmuth, Markus .

CANCER CELL, 2008, 14 (03) :238-249

[34] Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+ cell to Imatinib and Nilotinib [J].

Dillmann, Falk ;

Veldwijk, Marlon R. ;

Laufs, Stephanie ;

Sperandio, Markus ;

Calandra, Gary ;

Wenz, Frederik ;

Zeller, W. Jens ;

Fruehauf, Stefan .

LEUKEMIA & LYMPHOMA, 2009, 50 (10) :1676-1686

[35] Disruption of Bcr-Abl Coiled Coil Oligomerization by Design [J].

Dixon, Andrew S. ;

Pendley, Scott S. ;

Bruno, Benjamin J. ;

Woessner, David W. ;

Shimpi, Adrian A. ;

Cheatham, Thomas E., III ;

Lim, Carol S. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (31) :27751-27760

[36] BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571 [J].

Donato, NJ ;

Wu, JY ;

Stapley, J ;

Gallick, G ;

Lin, H ;

Arlinghaus, R ;

Talpaz, M .

BLOOD, 2003, 101 (02) :690-698

[37] Hematopoiesis: A Human Perspective [J].

Doulatov, Sergei ;

Notta, Faiyaz ;

Laurenti, Elisa ;

Dick, John E. .

CELL STEM CELL, 2012, 10 (02) :120-136

[38] Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells [J].

Druker, BJ ;

Tamura, S ;

Buchdunger, E ;

Ohno, S ;

Segal, GM ;

Fanning, S ;

Zimmermann, J ;

Lydon, NB .

NATURE MEDICINE, 1996, 2 (05) :561-566

[39] Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia [J].

Druker, Brian J. ;

Guilhot, Francois ;

O'Brien, Stephen G. ;

Gathmann, Insa ;

Kantarjian, Hagop ;

Gattermann, Norbert ;

Deininger, Michael W. N. ;

Silver, Richard T. ;

Goldman, John M. ;

Stone, Richard M. ;

Cervantes, Francisco ;

Hochhaus, Andreas ;

Powell, Bayard L. ;

Gabrilove, Janice L. ;

Rousselot, Philippe ;

Reiffers, Josy ;

Cornelissen, Jan J. ;

Hughes, Timothy ;

Agis, Hermine ;

Fischer, Thomas ;

Verhoef, Gregor ;

Shepherd, John ;

Saglio, Giuseppe ;

Gratwohl, Alois ;

Nielsen, Johan L. ;

Radich, Jerald P. ;

Simonsson, Bengt ;

Taylor, Kerry ;

Baccarani, Michele ;

So, Charlene ;

Letvak, Laurie ;

Larson, Richard A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (23) :2408-2417

[40] BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition [J].

Duy, Cihangir ;

Hurtz, Christian ;

Shojaee, Seyedmehdi ;

Cerchietti, Leandro ;

Geng, Huimin ;

Swaminathan, Srividya ;

Klemm, Lars ;

Kweon, Soo-mi ;

Nahar, Rahul ;

Braig, Melanie ;

Park, Eugene ;

Kim, Yong-mi ;

Hofmann, Wolf-Karsten ;

Herzog, Sebastian ;

Jumaa, Hassan ;

Koeffler, H. Phillip ;

Yu, J. Jessica ;

Heisterkamp, Nora ;

Graeber, Thomas G. ;

Wu, Hong ;

Ye, B. Hilda ;

Melnick, Ari ;

Mueschen, Markus .

NATURE, 2011, 473 (7347) :384-U572

← 1 2 3 4 5 6 7 8 9 10 →