Mcl-1: the 1 in CLL

被引：23

作者：

Gandhi, Varsha ^{[1
]}

Balakrishnan, Kumudha ^{[1
]}

Chen, Lisa S. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

来源：

BLOOD | 2008年 / 112卷 / 09期

关键词：

D O I：

10.1182/blood-2008-07-170241

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although Mcl-1 has been established as a survival and maintenance protein during in vitro incubations of primary CLL cells, in this issue of Blood, Pepper and colleagues further demonstrate the association of Mcl-1 with other prognostic factors and the role of this antiapoptotic protein in disease progression and outcome for patients with CLL.

引用

页码：3538 / 3540

页数：5

共 8 条

[1] Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells [J].

Balakrishnan, Kumudha ;

Wierda, William G. ;

Keating, Michael J. ;

Gandhi, Varsha .

BLOOD, 2008, 112 (05) :1971-1980

[2] CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment [J].

Burger, JA ;

Kipps, TJ .

BLOOD, 2006, 107 (05) :1761-1767

[3] Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death [J].

Chen, R ;

Keating, MJ ;

Gandhi, V ;

Plunkett, W .

BLOOD, 2005, 106 (07) :2513-2519

[4] Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: Correlations with in vitro and in vivo chemoresponses [J].

Kitada, S ;

Andersen, J ;

Akar, S ;

Zapata, JM ;

Takayama, S ;

Krajewski, S ;

Wang, HG ;

Zhang, X ;

Bullrich, F ;

Croce, CM ;

Rai, K ;

Hines, J ;

Reed, JC .

BLOOD, 1998, 91 (09) :3379-3389

[5] Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1 [J].

Maurer, U ;

Charvet, C ;

Wagman, AS ;

Dejardin, E ;

Green, DR .

MOLECULAR CELL, 2006, 21 (06) :749-760

[6] Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1 [J].

Opferman, JT ;

Letai, A ;

Beard, C ;

Sorcinelli, MD ;

Ong, CC ;

Korsmeyer, SJ .

NATURE, 2003, 426 (6967) :671-676

[7] Apoptosis-based therapies for hematologic malignancies [J].

Reed, JC ;

Pellecchia, M .

BLOOD, 2005, 106 (02) :408-418

[8] Multiple signaling pathways promote B lymphocyte stimulator-dependent B-cell growth and survival [J].

Woodland, Robert T. ;

Fox, Casey J. ;

Schmidt, Madelyn R. ;

Hammerman, Peter S. ;

Opferman, Joseph T. ;

Korsmeyer, Stanley J. ;

Hilbert, David M. ;

Thompson, Craig B. .

BLOOD, 2008, 111 (02) :750-760

← 1 →