Clinical and social characteristics of Korean men with Klinefelter syndrome

被引:6
|
作者
Bak, Chong Won [2 ,3 ]
Byun, Jae Sang [2 ,3 ]
Lee, Jee Han [2 ,3 ]
Park, Ji Hye
Lee, Kyung-Ah
Shim, Sung Han [1 ]
机构
[1] CHA Univ, CHA Gangnam Med Ctr, Fertil Ctr, Genet Lab, Seoul 135081, South Korea
[2] Ctr Reprod Med, Dept Androl, Seoul, South Korea
[3] Zaii Med Ctr, Zaii Urol Inst, Ctr Prostate, Seoul, South Korea
关键词
education level; Klinefelter syndrome; prostate; signs and symptoms; testosterone; TESTOSTERONE LEVELS; SPERM RETRIEVAL; 47; XXY; SPERMATOGENESIS; ADOLESCENTS; PREVALENCE; INJECTION; ANDROGEN; RECOVERY; HORMONE;
D O I
10.1111/j.1442-2042.2012.02964.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objectives: To investigate the characteristics of Klinefelter syndrome in a consecutive series of men consulting for sexual as well as fertility problems in Korea. Methods: A total of 179 men with non-mosaic 47, XXY Klinefelter syndrome of the 1876 azoospermic males who visited the fertility center of our university hospital between January 2002 and January 2010 were included in this analysis. Their semen characteristics, hormone profiles, size of the prostate gland, and education level were assessed and compared with an age-matched control group of 218 fertile males. Additionally, a histological evaluation was carried out. Results: Prostate size, testicular volume, semen volume and symptom severity showed statistically significant differences in both groups (P < 0.0001). As the severity of signs and symptoms worsened, the education level decreased. Each degree of signs and symptoms was associated with a different level of education, as well as with significant differences in the level of testosterone and testicular volume (P < 0.05). Spearman's correlation coefficient showed the severity of signs and symptoms was associated with testosterone (P < 0.0001). Conclusions: Testosterone has the strongest negative association with the severity of signs and symptoms in patients with Klinefelter syndrome. It influences the reproductive capacity, as well as the manifested signs and symptoms of hypogonadism. Furthermore, it is also associated with various aspects of life in these patients.
引用
收藏
页码:443 / 449
页数:7
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