Clinical and social characteristics of Korean men with Klinefelter syndrome
被引:6
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作者:
Bak, Chong Won
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机构:
Ctr Reprod Med, Dept Androl, Seoul, South Korea
Zaii Med Ctr, Zaii Urol Inst, Ctr Prostate, Seoul, South KoreaCHA Univ, CHA Gangnam Med Ctr, Fertil Ctr, Genet Lab, Seoul 135081, South Korea
Bak, Chong Won
[2
,3
]
Byun, Jae Sang
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机构:
Ctr Reprod Med, Dept Androl, Seoul, South Korea
Zaii Med Ctr, Zaii Urol Inst, Ctr Prostate, Seoul, South KoreaCHA Univ, CHA Gangnam Med Ctr, Fertil Ctr, Genet Lab, Seoul 135081, South Korea
Byun, Jae Sang
[2
,3
]
Lee, Jee Han
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机构:
Ctr Reprod Med, Dept Androl, Seoul, South Korea
Zaii Med Ctr, Zaii Urol Inst, Ctr Prostate, Seoul, South KoreaCHA Univ, CHA Gangnam Med Ctr, Fertil Ctr, Genet Lab, Seoul 135081, South Korea
Lee, Jee Han
[2
,3
]
Park, Ji Hye
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机构:CHA Univ, CHA Gangnam Med Ctr, Fertil Ctr, Genet Lab, Seoul 135081, South Korea
Park, Ji Hye
Lee, Kyung-Ah
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机构:CHA Univ, CHA Gangnam Med Ctr, Fertil Ctr, Genet Lab, Seoul 135081, South Korea
Lee, Kyung-Ah
Shim, Sung Han
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机构:
CHA Univ, CHA Gangnam Med Ctr, Fertil Ctr, Genet Lab, Seoul 135081, South KoreaCHA Univ, CHA Gangnam Med Ctr, Fertil Ctr, Genet Lab, Seoul 135081, South Korea
Shim, Sung Han
[1
]
机构:
[1] CHA Univ, CHA Gangnam Med Ctr, Fertil Ctr, Genet Lab, Seoul 135081, South Korea
[2] Ctr Reprod Med, Dept Androl, Seoul, South Korea
[3] Zaii Med Ctr, Zaii Urol Inst, Ctr Prostate, Seoul, South Korea
Objectives: To investigate the characteristics of Klinefelter syndrome in a consecutive series of men consulting for sexual as well as fertility problems in Korea. Methods: A total of 179 men with non-mosaic 47, XXY Klinefelter syndrome of the 1876 azoospermic males who visited the fertility center of our university hospital between January 2002 and January 2010 were included in this analysis. Their semen characteristics, hormone profiles, size of the prostate gland, and education level were assessed and compared with an age-matched control group of 218 fertile males. Additionally, a histological evaluation was carried out. Results: Prostate size, testicular volume, semen volume and symptom severity showed statistically significant differences in both groups (P < 0.0001). As the severity of signs and symptoms worsened, the education level decreased. Each degree of signs and symptoms was associated with a different level of education, as well as with significant differences in the level of testosterone and testicular volume (P < 0.05). Spearman's correlation coefficient showed the severity of signs and symptoms was associated with testosterone (P < 0.0001). Conclusions: Testosterone has the strongest negative association with the severity of signs and symptoms in patients with Klinefelter syndrome. It influences the reproductive capacity, as well as the manifested signs and symptoms of hypogonadism. Furthermore, it is also associated with various aspects of life in these patients.
机构:
Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea
Asan Med Ctr, Med Genet Ctr, Seoul, South Korea
Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Dept Pediat, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea
Yoon, Ji-Hee
Hwang, Soojin
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机构:
Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea
Asan Med Ctr, Med Genet Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea
Hwang, Soojin
Bae, Hyunwoo
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机构:
Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea
Asan Med Ctr, Med Genet Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea
Bae, Hyunwoo
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Kim, Dohyung
Seo, Go Hun
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机构:
3Billion Inc, Div Med Genet, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea
Seo, Go Hun
Koh, June-Young
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机构:
Inocras Inc, Daejeon, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea
Koh, June-Young
Ju, Young Seok
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机构:
Inocras Inc, Daejeon, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea
Ju, Young Seok
Do, Hyo-Sang
论文数: 0引用数: 0
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机构:
Asan Med Ctr, Asan Inst Life Sci, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea
Do, Hyo-Sang
Kim, Soyoung
论文数: 0引用数: 0
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机构:
Asan Med Ctr, Asan Inst Life Sci, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea
Kim, Soyoung
Kim, Gu-Hwan
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机构:
Asan Med Ctr, Med Genet Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea
Kim, Gu-Hwan
Kim, Ja Hye
论文数: 0引用数: 0
h-index: 0
机构:
Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea
Asan Med Ctr, Med Genet Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea
Kim, Ja Hye
Choi, Jin-Ho
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机构:
Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea
Asan Med Ctr, Med Genet Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea
机构:
Univ Beira Interior, CICS, Hlth Sci Res Ctr, Av Infante D Henrique, P-6201506 Covilha, PortugalUniv Beira Interior, CICS, Hlth Sci Res Ctr, Av Infante D Henrique, P-6201506 Covilha, Portugal
Alves, Marco G.
Martins, Ana D.
论文数: 0引用数: 0
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机构:
Univ Beira Interior, CICS, Hlth Sci Res Ctr, Av Infante D Henrique, P-6201506 Covilha, Portugal
Univ Porto, Inst Biomed Sci Abel Salazar ICBAS, Dept Microscopy, Cell Biol Lab, Rua Campo Alegre 823, P-4100 Oporto, Portugal
Univ Porto, Unit Multidisciplinary Res Biomed UMIB, Rua Campo Alegre 823, P-4100 Oporto, PortugalUniv Beira Interior, CICS, Hlth Sci Res Ctr, Av Infante D Henrique, P-6201506 Covilha, Portugal
Martins, Ana D.
Jarak, Ivana
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机构:
Univ Aveiro, Ctr Res Ceram & Composite Mat CICECO, P-3800 Aveiro, PortugalUniv Beira Interior, CICS, Hlth Sci Res Ctr, Av Infante D Henrique, P-6201506 Covilha, Portugal
Jarak, Ivana
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机构:
Barros, Alberto
Silva, Joaquina
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机构:
Ctr Reprod Genet Prof Alberto Barros, Oporto, PortugalUniv Beira Interior, CICS, Hlth Sci Res Ctr, Av Infante D Henrique, P-6201506 Covilha, Portugal
Silva, Joaquina
Sousa, Mario
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机构:
Univ Porto, Inst Biomed Sci Abel Salazar ICBAS, Dept Microscopy, Cell Biol Lab, Rua Campo Alegre 823, P-4100 Oporto, Portugal
Univ Porto, Unit Multidisciplinary Res Biomed UMIB, Rua Campo Alegre 823, P-4100 Oporto, Portugal
Ctr Reprod Genet Prof Alberto Barros, Oporto, PortugalUniv Beira Interior, CICS, Hlth Sci Res Ctr, Av Infante D Henrique, P-6201506 Covilha, Portugal
Sousa, Mario
Oliveira, Pedro F.
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机构:
Univ Porto, Inst Biomed Sci Abel Salazar ICBAS, Dept Microscopy, Cell Biol Lab, Rua Campo Alegre 823, P-4100 Oporto, Portugal
Univ Porto, Unit Multidisciplinary Res Biomed UMIB, Rua Campo Alegre 823, P-4100 Oporto, Portugal
Univ Porto, I3S Inst Hlth Res & Innovat, Rua Campo Alegre 823, P-4100 Oporto, PortugalUniv Beira Interior, CICS, Hlth Sci Res Ctr, Av Infante D Henrique, P-6201506 Covilha, Portugal
机构:
Cornell Univ, Dept Urol & Reprod Med, Weill Med Coll, New York, NY 10065 USA
Populat Council, Ctr Biomed Res, New York, NY 10021 USACornell Univ, Dept Urol & Reprod Med, Weill Med Coll, New York, NY 10065 USA
Paduch, Darius A.
Bolyakov, Alexander
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机构:
Cornell Univ, Dept Urol & Reprod Med, Weill Med Coll, New York, NY 10065 USACornell Univ, Dept Urol & Reprod Med, Weill Med Coll, New York, NY 10065 USA
Bolyakov, Alexander
Cohen, Paula
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机构:
Cornell Univ, Coll Vet Med, Dept Biomed Sci, Ithaca, NY 14853 USACornell Univ, Dept Urol & Reprod Med, Weill Med Coll, New York, NY 10065 USA
Cohen, Paula
Travis, Alexander
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机构:
Cornell Univ, Coll Vet Med, James A Baker Inst Anim Hlth, Ithaca, NY 14853 USACornell Univ, Dept Urol & Reprod Med, Weill Med Coll, New York, NY 10065 USA