"η6"-Type anion-π in biomolecular recognition

被引：41

作者：

Chakravarty, Suvobrata ^{[1
]}

Sheng, Zi-Zhang ^{[1
]}

Iverson, Bradley ^{[1
]}

Moore, Brian ^{[2
]}

机构：

[1] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA

[2] S Dakota State Univ, Off Informat Technol, Brookings, SD 57007 USA

来源：

FEBS LETTERS | 2012年 / 586卷 / 23期

关键词：

Non-covalent interaction; Anion-pi; Cation-pi; Evolutionary conservation; Nucleic acid tetraloop; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; TERNARY COMPLEX; PROTEIN; RESOLUTION; INSIGHTS;

D O I：

10.1016/j.febslet.2012.10.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Theoretical and compelling experimental evidence indicates that the interaction between an anion and an aromatic p system when the anion is directly above the ring face ("eta(6)"-type anion-pi), can be attractive. This may play an important role in the formation and recognition of biomolecular structures. We examined high-resolution structures of proteins and nucleic acids for the presence of "eta(6)"-type anion-pi. Though less frequent than its counterpart cation-pi, "eta(6)"-type anion-pi is observed unambiguously, occurring in protein/nucleic acid loops and often involving conserved/coevolving sites in proteins, suggesting it plays an important role in macromolecular folding and function. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：4180 / 4185

页数：6

共 27 条

[1] Structural versatility of anion-π interactions in halide salts with pentafluorophenyl substituted cations [J].

Albrecht, Markus ;

Wesselt, Claudia ;

de Groot, Marita ;

Rissanen, Kari ;

Luechow, Arne .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (14) :4600-+

[2] Is protein folding hierarchic? II. Folding intermediates and transition states [J].

Baldwin, RL ;

Rose, GD .

TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (02) :77-83

[3] Structure of the branched-chain keto acid decarboxylase (KdcA) from Lactococcus lactis provides insights into the structural basis for the chemoselective and enantioselective carboligation reaction [J].

Berthold, Catrine L. ;

Gocke, Doerte ;

Wood, D. ;

Leeper, Finian J. ;

Pohl, Martina ;

Schneider, Gunter .

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2007, 63 :1217-1224

[4] Residue depth: a novel parameter for the analysis of protein structure and stability [J].

Chakravarty, S ;

Varadarajan, R .

STRUCTURE WITH FOLDING & DESIGN, 1999, 7 (07) :723-732

[5]

Dawson RE, 2010, NAT CHEM, V2, P533, DOI [10.1038/NCHEM.657, 10.1038/nchem.657]

[6] Cation-pi interactions in chemistry and biology: A new view of benzene, Phe, Tyr, and Trp [J].

Dougherty, DA .

SCIENCE, 1996, 271 (5246) :163-168

[7] Interplay between Anion-π and Hydrogen Bonding Interactions [J].

Escudero, Daniel ;

Frontera, Antonio ;

Quinonero, David ;

Deya, Pere M. .

JOURNAL OF COMPUTATIONAL CHEMISTRY, 2009, 30 (01) :75-82

[8] Protein packing: Dependence on protein size, secondary structure and amino acid composition [J].

Fleming, PJ ;

Richards, FM .

JOURNAL OF MOLECULAR BIOLOGY, 2000, 299 (02) :487-498

[9] A computational study of cation-π interactions vs salt bridges in aqueous media:: Implications for protein engineering [J].

Gallivan, JP ;

Dougherty, DA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (05) :870-874

[10]

Heightman TD, 1999, ANGEW CHEM INT EDIT, V38, P750, DOI 10.1002/(SICI)1521-3773(19990315)38:6<750::AID-ANIE750>3.0.CO

← 1 2 3 →