Isothermal by Design: Comparison with an Established Isothermal Nucleation Kinetics Analysis Method

被引：3
作者：
Kaskiewicz, Peter L. [1 ]
Turner, Thomas D. [1 ]
Warren, Nicholas J. [1 ]
Morton, Colin [2 ]
Dowding, Peter J. [2 ]
George, Neil [3 ]
Roberts, Kevin J. [1 ]
机构：
[1] Univ Leeds, Sch Chem & Proc Engn, Leeds LS2 9JT, W Yorkshire, England
[2] Infineum UK Ltd, Milton Hill Business & Technol Ctr, Abingdon, Oxon, England
[3] Syngenta UK Ltd, Jealotts Hill Int Res Ctr, Bracknell, Berks, England
来源：
CHEMICAL ENGINEERING & TECHNOLOGY | 2020年 / 43卷 / 10期
基金：
英国工程与自然科学研究理事会;
关键词：
Antisolvent crystallization; Induction time; Isothermal; Kinetics; Nucleation; P-AMINOBENZOIC ACID; CRYSTALLIZATION;
D O I：
10.1002/ceat.202000113
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
The nucleation kinetics of the alpha form ofp-aminobenzoic acid from ethanolic and aqueous solutions is examined through a comparative examination of temperature-jump and anti-solvent drown-out isothermal crystallization methodologies. Analysis of the data reveals the measured induction times, and the calculated effective interfacial tensions as a function of the supersaturation show broadly equivalent behavior for the aqueous-ethanol mixed-solvent drown-out and temperature-jump ethanol solution systems, confirming the comparability of the two methodologies. The results also demonstrate poorer agreement with the temperature-jump pure aqueous system, highlighting the importance of the strength of solvation/desolvation as the key rate-limiting process for the overall nucleation behavior.
引用
收藏
页码：1971 / 1980
页数：10
相关论文
共 17 条
  • [1] [Anonymous], 2020, CRYSTAL16 TECHNOBIS
  • [2] Crystal nucleation and growth in a polymorphic system: Ostwald's rule, p-aminobenzoic acid and nucleation transition states
    Black, J. F. B.
    Cardew, P. T.
    Cruz-Cabeza, A. J.
    Davey, R. J.
    Gilks, S. E.
    Sullivan, R. A.
    [J]. CRYSTENGCOMM, 2018, 20 (06): : 768 - 776
  • [3] Nucleation mechanism and kinetics from the analysis of polythermal crystallisation data: methyl stearate from kerosene solutions
    Corzo, Diana M. Camacho
    Borissova, Antonia
    Hammond, Robert B.
    Kashchiev, Dimo
    Roberts, Kevin J.
    Lewtas, Ken
    More, Iain
    [J]. CRYSTENGCOMM, 2014, 16 (06): : 974 - 991
  • [4] Crystal Nucleation Rates from Probability Distributions of Induction Times
    Jiang, Shanfeng
    ter Horst, Joop H.
    [J]. CRYSTAL GROWTH & DESIGN, 2011, 11 (01) : 256 - 261
  • [5] Induction time in crystallization of gas hydrates
    Kashchiev, D
    Firoozabadi, A
    [J]. JOURNAL OF CRYSTAL GROWTH, 2003, 250 (3-4) : 499 - 515
  • [6] Kashchiev D., 2000, NUCLEATION
  • [7] Isothermal by Design: An Accelerated Approach to the Prediction of the Crystallizability of Slowly Nucleating Systems
    Kaskiewicz, Peter L.
    Xu, Guangyi
    Lai, Xiaojun
    Warren, Nicholas J.
    Roberts, Kevin J.
    Morton, Colin
    Dowding, Peter
    George, Neil
    [J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2019, 23 (09) : 1948 - 1959
  • [8] Nucleation and supersaturation in drowning-out crystallization using a T-mixer
    Kim, Kwang-Joo
    Kim, Jae-Kyung
    [J]. CHEMICAL ENGINEERING & TECHNOLOGY, 2006, 29 (08) : 951 - 956
  • [9] Crystal nucleation of salicylic acid in organic solvents
    Mealey, Donal
    Croker, Denise M.
    Rasmuson, Ake C.
    [J]. CRYSTENGCOMM, 2015, 17 (21): : 3961 - 3973
  • [10] Mullin J., 2001, CRYSTALLIZATION
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