Usefulness of tissue transglutaminase type 2 antibodies in early pregnancy

被引：1

作者：

Baldassarre, Maria Elisabetta ^{[1
,2
]}

Laneve, Annamaria ^{[1
,2
]}

Fontana, Antonietta ^{[3
]}

Manca, Fabio ^{[4
]}

Salvia, Gennaro ^{[5
]}

Barcaglioni, Patrizia ^{[6
]}

Cella, Adolfo ^{[7
]}

Giannuzzo, Silvia ^{[8
]}

Esposito, Luigi ^{[9
]}

Capursi, Teresa ^{[10
]}

Mastrorilli, Carla ^{[11
]}

Padovano, Alexander ^{[12
]}

Laforgia, Nicola ^{[1
,2
]}

机构：

[1] Univ Bari, Dept Gynecol Obstet & Neonatol, Sect Neonatol, I-70124 Bari, Italy

[2] Univ Bari, NICU, I-70124 Bari, Italy

[3] Azienda Osped Univ Consorziale Policlin UO Patol, Bari, Italy

[4] Univ Bari, Dip Sci Storiche & Geog, Sez Stat, Bari, Italy

[5] Osped Fatebenefratelli, NICU, Naples, Italy

[6] Azienda Osped SS Annunziata, NICU, Taranto, Italy

[7] Azienda Osped Univ Osped Riuniti, NICU, Foggia, Italy

[8] Osped Vito Fazzi, NICU, Lecce, Italy

[9] Osped Miulli Acquaviva Fonti BA, NICU, Bari, Italy

[10] Univ Bari, Sect Obstet, Dept Gynecol Obstet & Neonatol, Bari, Italy

[11] Univ Bari, Dept Pediat, Bari, Italy

[12] Washington Univ, St Louis, MO USA

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2012年 / 34卷 / 06期

关键词：

Pregnancy; small for gestational age newborns; celiac disease; screening; anti-transglutaminase antibodies; UNDIAGNOSED CELIAC-DISEASE; POPULATION-BASED COHORT; HIGH PREVALENCE; GENERAL-POPULATION; BLOOD-DONORS; CHILDREN; DIAGNOSIS; AUTOANTIBODIES; STRATEGIES; ADULTS;

D O I：

10.3109/08923973.2012.680470

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Celiac disease (CD), an autoimmune disease triggered by dietary gluten, is a multi-systemic disorder that primarily results in mucosal damage of the small intestine. Reproductive disorders and pregnancy complications have been associated with CD. Conflicting results have been published concerning CD and the risk of impaired fetal growth with reduced birthweight. The aim of our multicentric, perspective, case-control study was to determine the prevalence of undiagnosed CD in mothers of small for gestational age (SGA) newborns in two regions of Italy. The study included 480 mothers: group A consisted of 284 SGA newborns' mothers and group B consisted of 196 appropriate for gestational age (AGA) newborns' mothers. Tissue transglutaminase type 2 antibodies (TG2) IgA and IgG were measured in blood samples. We diagnosed two new cases of CD in asymptomatic mothers. It may be appropriate to include the TG2 to the panel of prenatal blood test.

引用

页码：932 / 936

页数：5

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