A Quantitative Measurement of Antiviral Activity of Anti-Human Immunodeficiency Virus Type 1 Drugs against Simian Immunodeficiency Virus Infection: Dose-Response Curve Slope Strongly Influences Class-Specific Inhibitory Potential

被引：10

作者：

Deng, Kai ^{[1
]}

Zink, M. Christine ^{[2
]}

Clements, Janice E. ^{[2
]}

Siliciano, Robert F. ^{[1
,3
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Mol & Comparat Pathobiol, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21205 USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 20期

关键词：

ANTIRETROVIRAL THERAPY; VIRAL LOAD; REVERSE-TRANSCRIPTASE; LATENT RESERVOIR; HIV-1; INFECTION; RHESUS MACAQUES; T-LYMPHOCYTES; MODEL; AIDS; SUPPRESSION;

D O I：

10.1128/JVI.01563-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Simian immunodeficiency virus (SIV) infection in macaques is so far the best animal model for human immunodeficiency virus type 1 (HIV-1) studies, but suppressing viral replication in infected animals remains challenging. Using a novel single-round infectivity assay, we quantitated the antiviral activities of antiretroviral drugs against SIV. Our results emphasize the importance of the dose-response curve slope in determining the inhibitory potential of antiretroviral drugs and provide useful information for regimen selection in treating SIV-infected animals in models of therapy and virus eradication.

引用

页码：11368 / 11372

页数：5

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