Co-detection in the pathogenesis of severe hand-foot-mouth disease

被引：38

作者：

Liu, Li-Juan ^{[1
]}

Xu, Hong-Mei ^{[2
]}

Li, Xiu-Jun ^{[3
]}

Wang, Jun ^{[2
]}

Wang, Xian-Jun ^{[4
]}

Ding, Shu-Jun ^{[4
]}

Tang, Fang ^{[5
]}

Wang, Jing ^{[1
]}

Zhang, Ying-Jie ^{[6
]}

机构：

[1] Chinese Acad Inspect & Quarantine, Inst Hlth Quarantine, Beijing 100123, Peoples R China

[2] Chongqing Med Univ, Childrens Hosp, Dept Diarrhea, Chongqing 400014, Peoples R China

[3] Shandong Univ, Dept Epidemiol & Hlth Stat, Jinan 250012, Peoples R China

[4] Shandong Prov Dis Prevent & Control Ctr, Dept Infect Dis Control, Jinan 250001, Peoples R China

[5] Chinese Peoples Armed Police Forces, Ctr Dis Control & Prevent, Beijing 102613, Peoples R China

[6] Chinese Ctr Dis Control & Prevent, Natl Ctr Publ Hlth Surveillance & Informat Serv, Beijing 102206, Peoples R China

来源：

ARCHIVES OF VIROLOGY | 2012年 / 157卷 / 11期

关键词：

Hand-foot-mouth disease; enterovirus; 71; co-detection; ENTEROVIRUS; 71; INFECTION; TAIWAN; CHILDREN; ENCEPHALOPATHY; COMPLICATIONS; OUTBREAK;

D O I：

10.1007/s00705-012-1396-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

It still needs to be elucidated whether co-detection of EV71 with other intestinal tract viruses plays a role in the pathogenesis of severe hand-foot-mouth disease (HFMD). A total of 680 stool specimens collected from clinically diagnosed mild and severe-HFMD patients were tested for EV71, CA16, norovirus, bocavirus and rotavirus. The results showed that EV71 was significantly associated with severe-HFMD patients. Co-detection of EV71 with norovirus and rotavirus was also significantly associated with severe-HFMD patients: The OR (95 % CI) value was 6.466 (2.735, 15.283) and 7.561 (3.560, 16.057), p < 0.001, respectively. Co-detection of EV71 with rotavirus or norovirus is probably associated with severe HFMD.

引用

页码：2219 / 2222

页数：4

共 18 条

[1] Neurodevelopment and cognition in children after enterovirus 71 infection [J].

Chang, Luan-Yin ;

Huang, Li-Min ;

Gau, Susan Shur-Fen ;

Wu, Yu-Yu ;

Hsia, Shao-Hsuan ;

Fan, Tsui-Yen ;

Lin, Kuang-Lin ;

Huang, Yhu-Chering ;

Lu, Chun-Yi ;

Lin, Tzou-Yien .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (12) :1226-1234

[2] Rotavirus encephalopathy: Pathogenesis reviewed [J].

Goldwater, PN ;

Rowland, K ;

Power, R ;

Thesinger, M ;

Abbott, K ;

Grieve, A ;

Palombo, EA ;

Masendycz, PJ ;

Wilkinson, I ;

Bear, J .

JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 2001, 37 (02) :206-209

[3] An epidemic of enterovirus 71 infection in Taiwan [J].

Ho, MT ;

Chen, ER ;

Hsu, KH ;

Twu, SJ ;

Chen, KT ;

Tsai, SF ;

Wang, JR ;

Shih, SR .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (13) :929-935

[4] Neurologic complications in children with enterovirus 71 infection [J].

Huang, CC ;

Liu, CC ;

Chang, YC ;

Chen, CY ;

Wang, ST ;

Yeh, TF .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (13) :936-942

[5] Norovirus-associated encephalopathy [J].

Ito, Shuichi ;

Takeshita, Saoko ;

Nezu, Atsuo ;

Aihara, Yukoh ;

Usuku, Shuzo ;

Noguchi, Yuzo ;

Yokota, Shumpei .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2006, 25 (07) :651-652

[6] An outbreak of enterovirus 71 infection in Taiwan, 1998: epidemiologic and clinical manifestations [J].

Liu, CC ;

Tseng, HW ;

Wang, SM ;

Wang, JR ;

Su, IJ .

JOURNAL OF CLINICAL VIROLOGY, 2000, 17 (01) :23-30

[7]

Ministry of Health The Executive Yuanm Taiwan ROC, 1998, MMWR-MORBID MORTAL W, V1998, P629

[8] NOROVIRUS ENCEPHALOPATHY IN A PREVIOUSLY HEALTHY CHILD [J].

Obinata, Kaoru ;

Okumura, Akihisa ;

Nakazawa, Tomoyuki ;

Kamata, Ayako ;

Niizuma, Takahiro ;

Kinoshita, Keiji ;

Shimizu, Toshiaki .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2010, 29 (11) :1057-1059

[9] Human enterovirus 71 disease in Sarawak, Malaysia: A prospective clinical, virological, and molecular epidemiological study [J].

Ooi, Mong How ;

Wong, See Chang ;

Podin, Yuwana ;

Akin, Winnie ;

del Sel, Syvia ;

Mohan, Anand ;

Chieng, Chae Hee ;

Perera, David ;

Clear, Daniela ;

Wong, Darin ;

Blake, Emma ;

Cardosa, Jane ;

Solomon, Tom .

CLINICAL INFECTIOUS DISEASES, 2007, 44 (05) :646-656

[10]

Qu XW, 2007, EMERG INFECT DIS, V13, P165

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