Effects of subinhibitory concentrations of antibiotics on SOS and DNA repair gene expression in Staphylococcus aureus

被引：73

作者：

Mesak, Lili Rosana ^{[1
]}

Miao, Vivian ^{[1
]}

Davies, Julian ^{[1
]}

机构：

[1] Univ British Columbia, Inst Life Sci, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z3, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 09期

关键词：

D O I：

10.1128/AAC.01599-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Reporter clones of Staphylococcus aureus with different SOS response- and DNA repair-associated promoterlux gene fusion constructs were constructed to study the effects of sub-MICs of antibiotics on the transcription of the SOS and methyl mismatch repair (MMR) genes. Fluoroquinolones (FQs) upmodulated both the SOS and the MMR genes. The patterns of antibiotic-induced transcriptional modulation were altered in FQ-resistant mutants.

引用

页码：3394 / 3397

页数：4

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