Protective effects of Geloina eros extract against carbon tetrachloride-induced hepatotoxicity in rats

被引：23

作者：

Yeh, Yen-Hung ^{[1
,2
]}

Hsieh, You-Liang ^{[3
]}

Lee, Ya-Ting ^{[4
]}

Hu, Chao-Chin ^{[5
]}

机构：

[1] Chung Shan Med Univ, Sch Hlth Diet & Ind Management, Taichung, Taiwan

[2] Chung Shan Med Univ Hosp, Dept Nutr, Taichung, Taiwan

[3] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan

[4] Chien Kuo Technol Univ, Dept Beauty Sci, Changhua, Taiwan

[5] Chung Shan Med Univ, Sch Appl Chem, Taichung, Taiwan

来源：

FOOD RESEARCH INTERNATIONAL | 2012年 / 48卷 / 02期

关键词：

Geloina eros extract; Antioxidant activity; Carbon tetrachloride; Hepatoprotective; Hepatotoxicity; LIVER; GLUTATHIONE; ACTIVATION;

D O I：

10.1016/j.foodres.2012.04.022

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

We investigated the effect of Geloina eros extract against carbon tetrachloride (CCl4)-induced hepatotoxicity. Our results showed that treatment with Geloina eros extract for 8 weeks significantly reduced the impact of CCl4 toxicity on the serum markers of liver damage, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) Antioxidant system was significantly enhanced in the plasma, and hepatic thiobarbituric acid reactive substance (TBARS) levels were lowered while the hepatic superoxide dismutase (SOD) and catalase (CAT) activities and glutathione peroxidase (GSH-Px) protein level and non-enzymatic antioxidants (vitamin E, vitamin C and GSH) were elevated. The results indicated that Geloina eros extract has a protective effect against acute hepatotoxicity induced by the administration of CCl4 and was found to be comparable to that of silymarin and have been supported by the evaluation of the liver histopathology in rats. The hepatoprotective effects of Geloina eros extract may be due to both the inhibition of lipid peroxidation and the increase of antioxidant activity. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：551 / 558

页数：8

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