Telomere Lengthening in CD8+ Cells in Polyclonal In Vitro Stimulation is Associated with an Increase in Protein Content of Catalytic Subunit of Telomerase (hTERT)

被引：0

作者：

Kozhevnikov, V. S. ^{[1
]}

Borisov, V. I. ^{[1
]}

Korolkova, O. Yu ^{[1
]}

Kozlov, V. A. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Clin Immunol, Siberian Div, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2012年 / 153卷 / 02期

关键词：

T lymphocytes; telomeres; telomerase; hTERT; CFSE; EXPRESSION; CAPACITY;

D O I：

10.1007/s10517-012-1682-z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Culturing of polyclonally activated T lymphocytes for 7 days in vitro leads to telomere lengthening in CD8(+), but not CD4(+) lymphocytes. Under these conditions, CD8(+) lymphocytes more intensively express telomerase catalytic subunit protein (hTERT) and divide more often than CD4(+) lymphocytes. It changes the ratio of CD4(+) and CD8(+) subpopulations in favor of the latter by the end of culturing.

引用

页码：226 / 228

页数：3

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