Synthesis and conformational studies of a hybrid cyclic peptide based on cis-β-furanoid sugar amino acid (FSAA) and ornithine

被引：6

作者：

Chandrasekhar, Srivari ^{[1
]}

Saritha, Birudaraju ^{[1
]}

Naresh, Police ^{[2
]}

Udayakiran, Marelli ^{[2
]}

Reddy, Chada Raji ^{[1
]}

Jagadeesh, Bharatam ^{[2
]}

机构：

[1] Indian Inst Chem Technol, Organ Div 1, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Ctr Nucl Magnet Resonance, Hyderabad 500007, Andhra Pradesh, India

来源：

HELVETICA CHIMICA ACTA | 2008年 / 91卷 / 07期

关键词：

D O I：

10.1002/hlca.200890138

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The conformational control of a 14-helix nucleating template, cis-beta-furanoid sugar amino acid (FSAA), over a flexible delta-amino acid, ornithine is studied in a FSAA-ornithine cyclic tetrapeptide. Extensive NMR and MD studies reveal that the cyclic peptide adopts a three-dimentional bowl-shape cavity, which promotes six- and seven-membered intra- and inter-residue H-bonding, in polar and non-polar solvents, respectively.

引用

页码：1267 / 1276

页数：10

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