Inhibition of nitric oxide synthase by benzoxazolones

被引：29

作者：

Shankaran, K

Donnelly, KL

Shah, SK

Humes, JL

Pacholok, SG

Grant, SK

Green, BG

MacCoss, M

机构：

[1] MERCK RES LABS,DEPT IMMUNOL & INFLAMMAT,RAHWAY,NJ 07065

[2] MERCK RES LABS,DEPT ENZYMOL,RAHWAY,NJ 07065

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(97)10101-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of benzoxazolones has been synthesized using modifications of literature methods. The synthetic benzoxazolone analogs, along with commercially available analogs, were evaluated as inhibitors of nitric oxide synthases (NOS). Structure-activity relationships are also discussed. (C) 1997 Elsevier Science Ltd.

引用

页码：2887 / 2892

页数：6

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