CSF chemokine levels in relapsing neuromyelitis optica and multiple sclerosis

被引：59
|
作者：
Narikawa, K
Misu, T
Fujihara, K
Nakashima, I
Sato, S
Itoyama, Y
机构：
[1] Tohoku Univ, Sch Med, Dept Neurol, Sendai, Miyagi 9808574, Japan
[2] Kohnan Hosp, Dept Neurol, Sendai, Miyagi 9828523, Japan
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2004年 / 149卷 / 1-2期
关键词：
relapsing neuromyelitis optica; multiple sclerosis; chemokine;
D O I：
10.1016/j.jneuroim.2003.12.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The pathogenesis of relapsing neuromyelitis optica (RNMO) remains unknown. We, for the first time, studied the levels of four chemokines in the cerebrospinal fluid in RNMO with ELISA and compared the data with those in multiple sclerosis (MS) and control. CXCL10/IP-10 and CCL17/TARC were significantly elevated in both RNMO and MS. Conversely, CCL2/MCP-1 was significantly lower in MS, but not in RNMO, than in control. CCL11/Eotaxin was not different between groups. None of the four chemokines studied was significantly different between RNMO and MS. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：182 / 186
页数：5
相关论文
共 50 条
  • [1] Increased levels of CSF CD59 in neuromyelitis optica and multiple sclerosis
    Uzawa, Akiyuki
    Mori, Masahiro
    Uchida, Tomohiko
    Masuda, Hiroki
    Ohtani, Ryohei
    Kuwabara, Satoshi
    CLINICA CHIMICA ACTA, 2016, 453 : 131 - 133
  • [2] Markedly increased CSF interleukin-6 levels in neuromyelitis optica, but not in multiple sclerosis
    Akiyuki Uzawa
    Masahiro Mori
    Michihiro Ito
    Tomohiko Uchida
    Sei Hayakawa
    Saeko Masuda
    Satoshi Kuwabara
    Journal of Neurology, 2009, 256 : 2082 - 2084
  • [3] Markedly increased CSF interleukin-6 levels in neuromyelitis optica, but not in multiple sclerosis
    Uzawa, Akiyuki
    Mori, Masahiro
    Ito, Michihiro
    Uchida, Tomohiko
    Hayakawa, Sei
    Masuda, Saeko
    Kuwabara, Satoshi
    JOURNAL OF NEUROLOGY, 2009, 256 (12) : 2082 - 2084
  • [4] Neuromyelitis optica and multiple sclerosis in sisters
    Cabrera-Gomez, J. A.
    Ramon-Perez, L.
    Saiz, A.
    Llerena-Fernandez, P.
    Fernandez-Fernandez, L.
    Ercilla, G.
    Grass-Fernandez, D.
    Robinson-Agramonte, M. A.
    Romero-Garcia, K.
    Macias-Betancourt, R.
    Galvizu-Sanchez, R.
    Otero-Motola, C.
    Sojo-Gomez, M.
    Aguilar-Arias, C.
    Rodriguez-Cordero, M.
    Gonzalez-Quevedo, A.
    MULTIPLE SCLEROSIS, 2009, 15 (02): : 269 - 271
  • [5] Expression of chemokine receptors on peripheral blood lymphocytes in multiple sclerosis and neuromyelitis optica
    Akiyuki Uzawa
    Masahiro Mori
    Sei Hayakawa
    Saeko Masuda
    Fumio Nomura
    Satoshi Kuwabara
    BMC Neurology, 10
  • [6] Neuromyelitis optica: not a multiple sclerosis variant
    Barnett, Michael H.
    Sutton, Ian
    CURRENT OPINION IN NEUROLOGY, 2012, 25 (03) : 215 - 220
  • [7] Serum level measurement of progranulin in relapsing-remitting multiple sclerosis and neuromyelitis optica patients
    Azadani, Niloufar Nasr
    Norouzi, Faezeh
    Hajizadeh, Mahsa
    Parsa, Sara
    Khalighinejad, Farnaz
    AMERICAN JOURNAL OF CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2019, 8 (03): : 16 - 20
  • [8] Relapsing demyelinating CNS disease in a Korean pediatric population: Multiple sclerosis versus neuromyelitis optica
    Lim, Byung Chan
    Hwang, Hee
    Kim, Ki Joong
    Hwang, Yong Seung
    Cheon, Jung-Eun
    Kim, In-One
    Kim, Ho Jin
    Chae, Jong-Hee
    MULTIPLE SCLEROSIS JOURNAL, 2011, 17 (01) : 67 - 73
  • [9] Neuromyelitis Optica and Asian Phenotype of Multiple Sclerosis
    Kira, Jun-ichi
    YEAR IN NEUROLOGY 2008, 2008, 1142 : 58 - 71
  • [10] Current symptomatology in multiple sclerosis and neuromyelitis optica
    Muto, M.
    Mori, M.
    Sato, Y.
    Uzawa, A.
    Masuda, S.
    Uchida, T.
    Kuwabara, S.
    EUROPEAN JOURNAL OF NEUROLOGY, 2015, 22 (02) : 299 - 304
12345