SAFETY, TOLERABILITY AND PHARMACOKINETIC OF GIC-1001 FOLLOWING MULTIPLE ASCENDING DOSES ADMINISTRATIONS THROUGH AN ADAPTIVE FIRST IN HUMAN STUDY IN HEALTHY VOLUNTEERS.

被引：0
|
作者：
Paquette, J. M. [1 ]
Rufiange, M. [1 ]
Sadoune, A. Ait [1 ]
Sicard, E. [1 ]
Massicotte, J. [1 ]
Lefebvre, M. [1 ]
Colin, P. [2 ]
Ranger, M. [2 ]
机构：
[1] Algorithme Pharma, Laval, PQ, Canada
[2] gIcare Pharma Inc, Montreal, PQ, Canada
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2014年 / 95卷
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：S61 / S61
页数：1
相关论文
共 50 条
  • [41] Safety, tolerability and pharmacokinetic findings from a first-in-human, randomized, double-blind, placebo-controlled trial of single and multiple ascending doses of PRAX-628 in healthy participants
    Hansen, K.
    Patel, D.
    Wehr, A.
    Frizzo, S.
    Petrou, S.
    Souza, M.
    EPILEPSIA, 2023, 64 : 522 - 522
  • [42] A Double-Blind, Randomised, Placebo-Controlled, Multiple Ascending Dose Study to Investigate Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Profile of Zamicastat, in Healthy Male Volunteers
    Magalhaes, L.
    Rocha, F.
    Falcao, A.
    Gama, H.
    Soares-Da-Silva, P.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201
  • [43] Single Ascending Dose Study to Assess Pharmacokinetic Linearity, Safety, and Tolerability of Trimetazidine - Modified Release in Healthy Human Subjects
    Koernicke, Thomas
    Arora, Deepa
    Samad, Abdus
    Kaplan, Sigal
    Domahidy, Monika
    de Voogd, Hanka
    Boehmert, Stella
    Ramos, Rita Silveira
    Jain, Shashank
    DRUG RESEARCH, 2020, 70 (10) : 472 - 477
  • [44] Multiple Rising Doses of Oral BI 1358894 in Healthy Male Volunteers: A Phase I Study to Investigate Safety and Tolerability
    Goettel, Markus
    Herich, Lena
    Wiebe, Sabrina
    Fuertig, Rene
    Sharma, Vikas
    Goettel, Markus
    BIOLOGICAL PSYCHIATRY, 2020, 87 (09) : S417 - S418
  • [45] First-in-Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of Pirepemat, a Cortical Enhancer, in Healthy Volunteers
    Rein-Hedin, Erik
    Sjoberg, Folke
    Waters, Susanna
    Sonesson, Clas
    Waters, Nicholas
    Huss, Fredrik
    Tedroff, Joakim
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2021, 10 (12): : 1485 - 1494
  • [46] FIRST-IN-HUMAN PHARMACOKINETIC, PHARMACODYNAMICS, AND SAFETY PROFILE OF A FAS ASSOCIATED FACTOR 1 INHIBITOR (KM-819) IN HEALTHY VOLUNTEERS.
    Shin, W.
    Kim, J.
    Lee, J.
    Kim, M. -K.
    Cho, D. -Y.
    Kim, H.
    Jhee, S.
    Lim, K.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2018, 103 : S49 - S50
  • [47] First-in-human study on pharmacokinetics, safety, and tolerability of single and multiple escalating doses of PA9159 nasal spray, a highly potent glucocorticoid in healthy Chinese volunteers
    Guo, Shaojie
    Hu, Yingchun
    Wang, Chengshuo
    Zhang, Yuan
    Wu, Feng
    Ni, Siyang
    Dai, Yuyang
    Han, Ying
    Hu, Minwan
    Lu, Chunping
    Xi, Zhijian
    Lu, Laichun
    Zhao, Xiuli
    Zhang, Luo
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2024, 200
  • [48] Effects of Single and Multiple Ascending Doses of BI 1358894 in Healthy Male Volunteers on Safety, Tolerability and Pharmacokinetics: Two Phase I Partially Randomised Studies
    Fuertig, Rene
    Goettel, Markus
    Herich, Lena
    Hoefler, Josef
    Wiebe, Sabrina T.
    Sharma, Vikas
    CNS DRUGS, 2023, 37 (12) : 1081 - 1097
  • [49] Effects of Single and Multiple Ascending Doses of BI 1358894 in Healthy Male Volunteers on Safety, Tolerability and Pharmacokinetics: Two Phase I Partially Randomised Studies
    René Fuertig
    Markus Goettel
    Lena Herich
    Josef Hoefler
    Sabrina T. Wiebe
    Vikas Sharma
    CNS Drugs, 2023, 37 : 1081 - 1097
  • [50] Pharmacokinetics, Safety, and Tolerability of Selonsertib, an Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Following First-in-Human Single and Multiple Ascending Doses in Healthy Subjects
    Nelson, Cara H.
    Etchevers, Kim
    Yi, Saili
    Breckenridge, David
    Hepner, Mischa
    Patel, Uptal
    Ling, John
    Mathias, Anita
    CLINICAL PHARMACOKINETICS, 2020, 59 (09) : 1109 - 1117
12345