PSMA-PET based radiotherapy: a review of initial experiences, survey on current practice and future perspectives

被引：35

作者：

Zschaeck, Sebastian ^{[1
,20
]}

Lohaus, Fabian ^{[2
,3
,4
]}

Beck, Marcus ^{[1
]}

Habl, Gregor ^{[5
,6
]}

Kroeze, Stephanie ^{[7
]}

Zamboglou, Constantinos ^{[8
,9
]}

Koerber, Stefan Alexander ^{[10
,11
,12
]}

Debus, Juergen ^{[10
,11
,12
]}

Hoelscher, Tobias ^{[2
,3
,4
]}

Wust, Peter ^{[1
]}

Ganswindt, Ute ^{[16
]}

Baur, Alexander D. J. ^{[17
]}

Zoephel, Klaus ^{[18
]}

Cihoric, Nikola ^{[19
]}

Guckenberger, Matthias ^{[7
]}

Combs, Stephanie E. ^{[6
,14
,15
]}

Grosu, Anca Ligia ^{[8
,9
]}

Ghadjar, Pirus ^{[1
]}

Belka, Claus ^{[13
,14
,15
]}

机构：

[1] Charite, Dept Radiat Oncol, Klin Radioonkol & Strahlentherapie, Berlin, Germany

[2] Tech Univ Dresden, Fac Med, Dept Radiat Oncol, Dresden, Germany

[3] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dresden, Germany

[4] Heidelberg & German Canc Consortium DKTK, German Canc Res Ctr DKFZ, Dresden, Germany

[5] Tech Univ Munich, Dept Radiat Oncol, Munich, Germany

[6] Helmholtz Zentrum Munchen HMGU, DRS, Inst Innovat Radiotherapy iRT, Munich, Germany

[7] Univ Hosp Zurich, Dept Radiat Oncol, Zurich, Switzerland

[8] Univ Freiburg, Dept Radiat Oncol, Med Ctr, Fac Med, Dresden, Germany

[9] German Canc Consortium DKTK, Partner Site Freiburg, Dresden, Germany

[10] Univ Hosp Heidelberg, Dept Radiat Oncol, Heidelberg, Germany

[11] German Canc Res Ctr, Heidelberg, Germany

[12] German Consortium translat Canc Res DKTK, Heidelberg, Germany

[13] Ludwig Maximilians Univ Munchen, Dept Radiat Oncol, Munich, Germany

[14] German Canc Res Ctr, Heidelberg, Germany

[15] German Canc Consortium DKTK, Partner Site Munich, Munich, Germany

[16] Innsbruck Med Univ, Dept Therapeut Radiol & Oncol, Innsbruck, Austria

[17] Univ Med Berlin, Dept Radiol, Berlin, Germany

[18] Univ Hosp Carl Gustav Carus, TU Dresden, Nucl Med Dept, Dresden, Germany

[19] Univ Bern, Bern Univ Hosp, Inselspital, Dept Radiat Oncol, Munchen, Switzerland

[20] Charite, Klin Radioonkol & Strahlentherapie, Augustenburger Pl 1, D-13353 Berlin, Germany

来源：

RADIATION ONCOLOGY | 2018年 / 13卷

关键词：

PSMA-PET; Prostate-cancer; Salvage radiotherapy; Primary radiotherapy; Image guided treatment planning; Review; Survey; POSITRON-EMISSION-TOMOGRAPHY; LOCALIZED PROSTATE-CANCER; GA-68-PSMA LIGAND PET/CT; MEMBRANE ANTIGEN; RADICAL PROSTATECTOMY; RADIATION TREATMENT; BIOCHEMICAL RECURRENCE; DIAGNOSTIC-ACCURACY; THERAPY; PSA;

D O I：

10.1186/s13014-018-1047-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

(68)Gallium prostate specific membrane antigen (PSMA) ligand positron emission tomography (PET) is an increasingly used imaging modality in prostate cancer, especially in cases of tumor recurrence after curative intended therapy. Owed to the novelty of the PSMA-targeting tracers, clinical evidence on the value of PSMA-PET is moderate but rapidly increasing. State of the art imaging is pivotal for radiotherapy treatment planning as it may affect dose prescription, target delineation and use of concomitant therapy. This review summarizes the evidence on PSMA-PET imaging from a radiation oncologist's point of view. Additionally a short survey containing twelve examples of patients and 6 additional questions was performed in seven mayor academic centers with experience in PSMA ligand imaging and the findings are reported here.

引用

页数：9

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