PSMA-PET based radiotherapy: a review of initial experiences, survey on current practice and future perspectives

被引：35

作者：

Zschaeck, Sebastian ^{[1
,20
]}

Lohaus, Fabian ^{[2
,3
,4
]}

Beck, Marcus ^{[1
]}

Habl, Gregor ^{[5
,6
]}

Kroeze, Stephanie ^{[7
]}

Zamboglou, Constantinos ^{[8
,9
]}

Koerber, Stefan Alexander ^{[10
,11
,12
]}

Debus, Juergen ^{[10
,11
,12
]}

Hoelscher, Tobias ^{[2
,3
,4
]}

Wust, Peter ^{[1
]}

Ganswindt, Ute ^{[16
]}

Baur, Alexander D. J. ^{[17
]}

Zoephel, Klaus ^{[18
]}

Cihoric, Nikola ^{[19
]}

Guckenberger, Matthias ^{[7
]}

Combs, Stephanie E. ^{[6
,14
,15
]}

Grosu, Anca Ligia ^{[8
,9
]}

Ghadjar, Pirus ^{[1
]}

Belka, Claus ^{[13
,14
,15
]}

机构：

[1] Charite, Dept Radiat Oncol, Klin Radioonkol & Strahlentherapie, Berlin, Germany

[2] Tech Univ Dresden, Fac Med, Dept Radiat Oncol, Dresden, Germany

[3] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dresden, Germany

[4] Heidelberg & German Canc Consortium DKTK, German Canc Res Ctr DKFZ, Dresden, Germany

[5] Tech Univ Munich, Dept Radiat Oncol, Munich, Germany

[6] Helmholtz Zentrum Munchen HMGU, DRS, Inst Innovat Radiotherapy iRT, Munich, Germany

[7] Univ Hosp Zurich, Dept Radiat Oncol, Zurich, Switzerland

[8] Univ Freiburg, Dept Radiat Oncol, Med Ctr, Fac Med, Dresden, Germany

[9] German Canc Consortium DKTK, Partner Site Freiburg, Dresden, Germany

[10] Univ Hosp Heidelberg, Dept Radiat Oncol, Heidelberg, Germany

[11] German Canc Res Ctr, Heidelberg, Germany

[12] German Consortium translat Canc Res DKTK, Heidelberg, Germany

[13] Ludwig Maximilians Univ Munchen, Dept Radiat Oncol, Munich, Germany

[14] German Canc Res Ctr, Heidelberg, Germany

[15] German Canc Consortium DKTK, Partner Site Munich, Munich, Germany

[16] Innsbruck Med Univ, Dept Therapeut Radiol & Oncol, Innsbruck, Austria

[17] Univ Med Berlin, Dept Radiol, Berlin, Germany

[18] Univ Hosp Carl Gustav Carus, TU Dresden, Nucl Med Dept, Dresden, Germany

[19] Univ Bern, Bern Univ Hosp, Inselspital, Dept Radiat Oncol, Munchen, Switzerland

[20] Charite, Klin Radioonkol & Strahlentherapie, Augustenburger Pl 1, D-13353 Berlin, Germany

来源：

RADIATION ONCOLOGY | 2018年 / 13卷

关键词：

PSMA-PET; Prostate-cancer; Salvage radiotherapy; Primary radiotherapy; Image guided treatment planning; Review; Survey; POSITRON-EMISSION-TOMOGRAPHY; LOCALIZED PROSTATE-CANCER; GA-68-PSMA LIGAND PET/CT; MEMBRANE ANTIGEN; RADICAL PROSTATECTOMY; RADIATION TREATMENT; BIOCHEMICAL RECURRENCE; DIAGNOSTIC-ACCURACY; THERAPY; PSA;

D O I：

10.1186/s13014-018-1047-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

(68)Gallium prostate specific membrane antigen (PSMA) ligand positron emission tomography (PET) is an increasingly used imaging modality in prostate cancer, especially in cases of tumor recurrence after curative intended therapy. Owed to the novelty of the PSMA-targeting tracers, clinical evidence on the value of PSMA-PET is moderate but rapidly increasing. State of the art imaging is pivotal for radiotherapy treatment planning as it may affect dose prescription, target delineation and use of concomitant therapy. This review summarizes the evidence on PSMA-PET imaging from a radiation oncologist's point of view. Additionally a short survey containing twelve examples of patients and 6 additional questions was performed in seven mayor academic centers with experience in PSMA ligand imaging and the findings are reported here.

引用

页数：9

共 23 条

[1] PSMA-PET based radiotherapy: a review of initial experiences, survey on current practice and future perspectives
Sebastian Zschaeck
Fabian Lohaus
Marcus Beck
Gregor Habl
Stephanie Kroeze
Constantinos Zamboglou
Stefan Alexander Koerber
Jürgen Debus
Tobias Hölscher
Peter Wust
Ute Ganswindt
Alexander D. J. Baur
Klaus Zöphel
Nikola Cihoric
Matthias Guckenberger
Stephanie E. Combs
Anca Ligia Grosu
Pirus Ghadjar
Claus Belka
Radiation Oncology, 13
[2] New perspectives on metabolic imaging in the management of prostate cancer in 2022: A focus on radiolabeled PSMA-PET/CT (Review)
Simon, Helene
Henkel, Daniel
Chiron, Paul
Helissey, Carole
MOLECULAR AND CLINICAL ONCOLOGY, 2023, 19 (01)
[3] Prostate-specific membran antigen targeting positron emission tomography (PSMA-PET) in prostate cancer in France in 2023: Current use and perspectives
Chanchou, M.
Robin, P.
MEDECINE NUCLEAIRE-IMAGERIE FONCTIONNELLE ET METABOLIQUE, 2023, 47 (05): : 258 - 265
[4] Outcome after PSMA-PET/CT-based salvage radiotherapy for nodal recurrence after radical prostatectomy
Rogowski, Paul
Trapp, Christian
von Bestenbostel, Rieke
Eze, Chukwuka
Ganswindt, Ute
Li, Minglun
Unterrainer, Marcus
Zacherl, Mathias J.
Ilhan, Harun
Beyer, Leonie
Kretschmer, Alexander
Bartenstein, Peter
Stief, Christian
Belka, Claus
Schmidt-Hegemann, Nina-Sophie
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2022, 49 (04) : 1417 - 1428
[5] Radiotherapy treatment modification for prostate cancer patients based on PSMA-PET/CT
Karagiannis, Vasileios
Wichmann, Viktor
Saarinen, Juha
Eigeliene, Natalja
Andersen, Heidi
Jekunen, Antti
RADIATION ONCOLOGY, 2022, 17 (01)
[6] Current and potential future role of PSMA-PET in patients with castration-resistant prostate cancer
Fankhauser, Christian Daniel
Poyet, Cedric
Kroeze, Stephanie G. C.
Kranzbuhler, Benedikt
Schuler, Helena I. Garcia
Guckenberger, Matthias
Kaufmann, Philipp A.
Hermanns, Thomas
Burger, Irene A.
WORLD JOURNAL OF UROLOGY, 2019, 37 (03) : 457 - 467
[7] Radiotherapy treatment modification for prostate cancer patients based on PSMA-PET/CT
Vasileios Karagiannis
Viktor Wichmann
Juha Saarinen
Natalja Eigeliene
Heidi Andersen
Antti Jekunen
Radiation Oncology, 17
[8] Current and potential future role of PSMA-PET in patients with castration-resistant prostate cancer
Christian Daniel Fankhauser
Cédric Poyet
Stephanie G. C. Kroeze
Benedikt Kranzbühler
Helena I. Garcia Schüler
Matthias Guckenberger
Philipp A. Kaufmann
Thomas Hermanns
Irene A. Burger
World Journal of Urology, 2019, 37 : 457 - 467
[9] Outcome after PSMA-PET/CT-based salvage radiotherapy for nodal recurrence after radical prostatectomy
Paul Rogowski
Christian Trapp
Rieke von Bestenbostel
Chukwuka Eze
Ute Ganswindt
Minglun Li
Marcus Unterrainer
Mathias J. Zacherl
Harun Ilhan
Leonie Beyer
Alexander Kretschmer
Peter Bartenstein
Christian Stief
Claus Belka
Nina-Sophie Schmidt-Hegemann
European Journal of Nuclear Medicine and Molecular Imaging, 2022, 49 : 1417 - 1428
[10] 18F-Fluoroestradiol (FES) PET/CT: review of current practice and future directions
O'Brien, Sophia R.
Edmonds, Christine E.
Katz, Danielle
Mankoff, David A.
Pantel, Austin R.
CLINICAL AND TRANSLATIONAL IMAGING, 2022, 10 (04) : 331 - 341

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