Development of a Standardized Set of Patient-centered Outcomes for Advanced Prostate Cancer: An International Effort for a Unified Approach

被引：84

作者：

Morgans, Alicia K. ^{[1
]}

van Bommel, Annelotte C. M. ^{[2
,3
]}

Stowell, Caleb ^{[2
]}

Abrahm, Janet L. ^{[4
]}

Basch, Ethan ^{[5
]}

Bekelman, Justin E. ^{[6
]}

Berry, Donna L. ^{[4
]}

Bossi, Alberto ^{[7
]}

Davis, Ian D. ^{[8
]}

de Reijke, Theo M. ^{[9
]}

Denis, Louis J. ^{[10
,11
]}

Evans, Sue M. ^{[12
]}

Fleshner, Neil E. ^{[13
]}

George, Daniel J. ^{[14
]}

Kiefert, Jim ^{[15
]}

Lin, Daniel W. ^{[16
]}

Matthew, Andrew G. ^{[13
]}

McDermott, Ray ^{[17
]}

Payne, Heather ^{[18
]}

Roos, Ian A. G. ^{[19
]}

Schrag, Deborah ^{[4
]}

Steuber, Thomas ^{[20
]}

Tombal, Bertrand ^{[21
]}

van Basten, Jean-Paul ^{[22
]}

van der Hoeven, Jacobus J. M. ^{[23
]}

Penson, David F. ^{[1
,24
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Nashville, TN 37232 USA

[2] Int Consortium Hlth Outcomes Measurement, Cambridge, MA USA

[3] Dutch Inst Clin Auditing, Leiden, Netherlands

[4] Dana Farber Canc Inst, Boston, MA 02115 USA

[5] Univ N Carolina, Chapel Hill, NC USA

[6] Univ Penn, Philadelphia, PA 19104 USA

[7] Gustave Roussy Canc Inst, Villejuif, France

[8] Monash Univ, Eastern Hlth Clin Sch, Melbourne, Vic 3004, Australia

[9] Acad Med Ctr Amsterdam, Amsterdam, Netherlands

[10] Oncol Ctr Antwerp, Antwerp, Belgium

[11] US TOO Belgium, Antwerp, Belgium

[12] Monash Univ, Melbourne, Vic 3004, Australia

[13] Univ Toronto, Toronto, ON, Canada

[14] Duke Univ, Med Ctr, Durham, NC USA

[15] US TOO Int, Des Plaines, IL USA

[16] Univ Washington, Seattle, WA 98195 USA

[17] St Vincents Univ Hosp, Dublin 4, Ireland

[18] Univ Coll London Hosp, London, England

[19] Canc Act Victoria, Melbourne, Vic, Australia

[20] Univ Hosp Hamburg Eppendorf, Hamburg, Germany

[21] Catholic Univ Louvain, Clin Univ St Luc, B-1200 Brussels, Belgium

[22] Canisius Wilhelmina Hosp, Nijmegen, Netherlands

[23] Leiden Univ, Med Ctr, Leiden, Netherlands

[24] VA Tennessee Valley Geriatr Res Educ & Clin Ctr G, Nashville, TN USA

来源：

EUROPEAN UROLOGY | 2015年 / 68卷 / 05期

关键词：

Outcome assessment (health care); Patient-centered care; Prostate cancer; Quality indicators; Health care; Palliative care; QUALITY-OF-LIFE; SOCIOECONOMIC-STATUS; INDEX COMPOSITE; CLINICAL-TRIALS; MEN; RECOMMENDATIONS; COMORBIDITY; VALIDATION; INSTRUMENT; GUIDELINES;

D O I：

10.1016/j.eururo.2015.06.007

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background: There are no universally monitored outcomes relevant to men with advanced prostate cancer, making it challenging to compare health outcomes between populations. Objective: We sought to develop a standard set of outcomes relevant to men with advanced prostate cancer to follow during routine clinical care. Design, setting, and participants: The International Consortium for Health Outcomes Measurement assembled a multidisciplinary working group to develop the set. Outcome measurements and statistical analysis: We used a modified Delphi method to achieve consensus regarding the outcomes, measures, and case mix factors included. Results and limitations: The 25 members of the multidisciplinary international working group represented academic and nonacademic centers, registries, and patients. Recognizing the heterogeneity of men with advanced prostate cancer, the group defined the scope as men with all stages of incurable prostate cancer (metastatic and biochemical recurrence ineligible for further curative therapy). Wedefined outcomes important to all men, such as overall survival, and measures specific to subgroups, such as time to metastasis. Measures gathered from clinical data include measures of disease control. We also identified patient-reported outcome measures (PROMs), such as degree of urinary, bowel, and erectile dysfunction, mood symptoms, and pain control. Conclusions: The international multidisciplinary group identified clinical data and PROMs that serve as a basis for international health outcome comparisons and quality-of-care assessments. The set will be revised annually. Patient summary: Our international group has recommended a standardized set of patient-centered outcomes to be followed during routine care for all men with advanced prostate cancer. (C) 2015 European Association of Urology. Published by Elsevier B.V. All rights reserved.

引用

页码：891 / 898

页数：8

共 29 条

[1] THE EUROPEAN-ORGANIZATION-FOR-RESEARCH-AND-TREATMENT-OF-CANCER QLQ-C30 - A QUALITY-OF-LIFE INSTRUMENT FOR USE IN INTERNATIONAL CLINICAL-TRIALS IN ONCOLOGY [J].