GSTP1 methylation in cancer: a liquid biopsy biomarker?

被引：46
作者：
Gurioli, Giorgia [1 ]
Martignano, Filippo [1 ,2 ]
Salvi, Samanta [1 ]
Costantini, Matteo [3 ]
Gunelli, Roberta [4 ]
Casadio, Valentina [1 ]
机构：
[1] IRCCS, Ist Sci Romagnolo Studio & Cura Tumori IRST, Biosci Lab, Via P Maroncelli 40, I-47014 Meldola, FC, Italy
[2] Univ Siena, Dept Med Biotechnol, Siena, Italy
[3] Morgagni Pierantoni Hosp, Dept Med Oncol, Pathol Unit, Forli, Italy
[4] Morgagni Pierantoni Hosp, Dept Urol, Forli, Italy
来源：
CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2018年 / 56卷 / 05期
关键词：
cancer; GSTP1; methylation; plasma; serum; tissue; urine; CPG ISLAND HYPERMETHYLATION; ABERRANT PROMOTER METHYLATION; CELL-FREE DNA; POLYMERASE-CHAIN-REACTION; TUMOR-RELATED GENES; 48 CANDIDATE GENES; S-TRANSFERASE-PI; PROSTATE-CANCER; BREAST-CANCER; MULTIPLE GENES;
D O I：
10.1515/cclm-2017-0703
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
The coding region of GSTP1 gene is preceded by a large CpG-rich region that is frequently affected by methylation. In many cancer types, GSTP1 is affected by hypermethylation and, as a consequence, it has a low expression. The aim of this review is to give an overview on GSTP1 methylation studies with a special focus on liquid biopsy, thus to summarize methods, results, sample types, different diseases, to have a complete information regarding this promising epigenetic biomarker. We used all the most valuable scientific search engines (PubMed, Medline, Scopus and Web of Science) searching the following keywords: GSTP1, methylation, cancer, urine, serum, plasma and blood. GSTP1 is a largely investigated tissue biomarker in several malignancies such as prostate, breast, lung and hepatocellular carcinoma with good performances especially for diagnostic purposes. As a liquid biopsy biomarker, it has been mainly investigated in prostate cancer (PCa) where it showed a high specificity but a low sensitivity; thus, it is recommended in combination with other biomarkers. Despite the large number of published papers and the promising results, GSTP1 has not yet entered the clinical practice even for PCa diagnosis. For this reason, further large and prospective studies are needed to validate this assay.
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页码：702 / 717
页数：16
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