Pregnancy protection of breast cancer: new insights reveal unanswered questions

被引：9
作者：
Medina, Daniel [1 ]
机构：
[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
来源：
BREAST CANCER RESEARCH | 2013年 / 15卷 / 03期
关键词：
MAMMARY-GLAND; CELLS; MOUSE; EXPRESSION; SIGNATURE;
D O I：
10.1186/bcr3414
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The recent paper by Meier-Abt and colleagues on pregnancy protection of breast cancer development takes a diff erent approach to the problem and focused on the eff ect of parity on the cell subpopulations of the mouse mammary gland. Their results demonstrate that parity decreases the cell number of the hormone receptor-positive luminal cells (that is, luminal Sca1+) but not the basal stem/ progenitor cells (CD24lo/CD49hi). Additionally, microarray studies demonstrate that wnt4 expression from the luminal Sca1+ cells is markedly reduced as is the wnt signaling pathway in basal cells. One important implication from these results is that targeting the wnt signaling pathway might be a feasible prevention approach in humans.
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共 13 条
  • [1] Hormone-induced protection against mammary tumorigenesis is conserved in multiple rat strains and identifies a core gene expression signature induced by pregnancy
    Blakely, Collin M.
    Stoddard, Alexander J.
    Belka, George K.
    Dugan, Katherine D.
    Notarfrancesco, Kathleen L.
    Moody, Susan E.
    D'Cruz, Celina M.
    Chodosh, Lewis A.
    [J]. CANCER RESEARCH, 2006, 66 (12) : 6421 - 6431
  • [2] Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-β1 expression
    Boulanger, CA
    Wagner, KU
    Smith, GH
    [J]. ONCOGENE, 2005, 24 (04) : 552 - 560
  • [3] Pregnancy in the mature adult mouse does not alter the proportion of mammary epithelial stem/progenitor cells
    Britt, Kara L.
    Kendrick, Howard
    Regan, Joseph L.
    Molyneux, Gemma
    Magnay, Fiona-Ann
    Ashworth, Alan
    Smalley, Matthew J.
    [J]. BREAST CANCER RESEARCH, 2009, 11 (02)
  • [4] Reprogramming non-mammary and cancer cells in the developing mouse mammary gland
    Bruno, Robert D.
    Smith, Gilbert H.
    [J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2012, 23 (05) : 591 - 598
  • [5] MACMAHON B, 1970, B WORLD HEALTH ORGAN, V43, P209
  • [6] Medina D, 2005, ENDOCR RELAT CANCER, V12, P1
  • [7] Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium
    Meier-Abt, Fabienne
    Milani, Emanuela
    Roloff, Tim
    Brinkhaus, Heike
    Duss, Stephan
    Meyer, Dominique S.
    Klebba, Ina
    Balwierz, Piotr J.
    van Nimwegen, Erik
    Bentires-Alj, Mohamed
    [J]. BREAST CANCER RESEARCH, 2013, 15 (02):
  • [8] Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia
    Moraes, Ricardo C.
    Zhang, Xiaomei
    Harrington, Nikesha
    Fung, Jennifer Y.
    Wu, Meng-Fen
    Hilsenbeck, Susan G.
    Allred, D. Craig
    Lewis, Michael T.
    [J]. DEVELOPMENT, 2007, 134 (06): : 1231 - 1242
  • [9] Defining the genomic signature of the parous breast
    Peri, Suraj
    de Cicco, Ricardo Lopez
    Santucci-Pereira, Julia
    Slifker, Michael
    Ross, Eric A.
    Russo, Irma H.
    Russo, Patricia A.
    Arslan, Alan A.
    Belitskaya-Levy, Ilana
    Zeleniuch-Jacquotte, Anne
    Bordas, Pal
    Lenner, Per
    Ahman, Janet
    Afanasyeva, Yelena
    Johansson, Robert
    Sheriff, Fathima
    Hallmans, Goeran
    Toniolo, Paolo
    Russo, Jose
    [J]. BMC MEDICAL GENOMICS, 2012, 5
  • [10] Effects of Age and Parity on Mammary Gland Lesions and Progenitor Cells in the FVB/N-RC Mice
    Raafat, Ahmed
    Strizzi, Luigi
    Lashin, Karim
    Ginsburg, Erika
    McCurdy, David
    Salomon, David
    Smith, Gilbert H.
    Medina, Daniel
    Callahan, Robert
    [J]. PLOS ONE, 2012, 7 (08):
12