Postoperative development of children after hemispherotomy

被引:61
作者
Maehara, T
Shimizu, H
Kawai, K
Shigetomo, R
Tamagawa, K
Yamada, T
Inoue, M
机构
[1] Tokyo Metropolitan Neurol Hosp, Dept Neurosurg, Fuchu, Tokyo 1830042, Japan
[2] Tokyo Metropolitan Neurol Hosp, Dept Neuropediat, Fuchu, Tokyo 1830042, Japan
[3] Tokyo Metropolitan Neurol Hosp, Dept Neuropsychiat, Fuchu, Tokyo 1830042, Japan
关键词
hemispherectomy; hemimegalencephaly; focal cortical dysplasia; development; children;
D O I
10.1016/S0387-7604(02)00010-4
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We studied the postoperative development of 14 children with cortical dysgenesis who underwent modified functional hemispherectomy (hemispherotomy) at the age of 6 years or younger. At follow-up of 24-72 months (median of 47 months), six (43%) were seizure-free, six achieved > 90% reduction, one achieved 50-90% reduction, and one achieved 0-50% reduction in seizure frequency. At the preoperative and final postoperative examinations, mean scores of developmental quotient (DQ) were as follows: 25.5 and 31.9 in total DQ, 26.0 and 33.7 in intellectual DQ, and 27.4 and 22.9 in motor DQ. Children scoring > 50 points in preoperative intellectual DQ score obtained near-normal intellectual DQ postoperatively, while, those scoring < 10 DQ preoperatively remained at a low developmental level. Among children with DQ scores in the range from 10 to 50. two children who obtained seizure-free outcome and were operated upon in the first 3 years of life achieved marked developmental progress. The present study indicated that high preoperative intellectual DQ and cessation of seizures seem to be associated with better postoperative intellectual development. However, long-term observation of postoperative development and an accumulation of more cases will be needed before we can reach a firm conclusion. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:155 / 160
页数:6
相关论文
共 23 条
[1]  
Asarnow RF, 1997, DEV MED CHILD NEUROL, V39, P430
[2]   Neuro-cognitive development and epilepsy outcome in children with surgically treated hemimegalencephaly [J].
Battaglia, D ;
Di Rocco, C ;
Iuvone, L ;
Acquafondata, C ;
Iannelli, A ;
Lettori, D ;
Guzzetta, F .
NEUROPEDIATRICS, 1999, 30 (06) :307-313
[3]   CONVULSIVE DISORDERS IN THE 1ST YEAR OF LIFE - PERSISTENCE OF EPILEPTIC SEIZURES [J].
CHEVRIE, JJ ;
AICARDI, J .
EPILEPSIA, 1979, 20 (06) :643-649
[4]   INFANTILE SPASMS .1. PET IDENTIFIES FOCAL CORTICAL DYSGENESIS IN CRYPTOGENIC CASES FOR SURGICAL-TREATMENT [J].
CHUGANI, HT ;
SHIELDS, WD ;
SHEWMON, DA ;
OLSON, DM ;
PHELPS, ME ;
PEACOCK, WJ .
ANNALS OF NEUROLOGY, 1990, 27 (04) :406-413
[5]   Age and etiology as predictors of language outcome following hemispherectomy [J].
Curtiss, S ;
de Bode, S .
DEVELOPMENTAL NEUROSCIENCE, 1999, 21 (3-5) :174-181
[6]   Bacterial pathogens isolated from patients with skin and soft tissue infections: Frequency of occurrence and antimicrobial susceptibility patterns from the SENTRY Antimicrobial Surveillance Program (United States and Canada, 1997) [J].
Doern, GV ;
Jones, RN ;
Pfaller, MA ;
Kugler, KC ;
Beach, ML .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1999, 34 (01) :65-72
[7]   Epilepsy surgery in the first three years of life [J].
Duchowny, M ;
Jayakar, P ;
Resnick, T ;
Harvey, AS ;
Alvarez, L ;
Dean, P ;
Gilman, J ;
Yaylali, I ;
Morrison, G ;
Prats, A ;
Altman, N ;
Birchansky, S ;
Bruce, J .
EPILEPSIA, 1998, 39 (07) :737-743
[8]  
Engel J, 1993, SURG TREATMENT EPILE, P609
[9]  
IKUZAWA M, 1995, KYOTO SCALE PSYCHOLO
[10]  
IKUZAWA M, 1990, P 22 INT C APPL PSYC, V2, P288