Dehydrocurvularin is a potent antineoplastic agent irreversibly blocking ATP-citrate lyase: evidence from chemoproteomics

被引：25
作者：
Deng, Zhangshuang [1 ,2 ,3 ]
Wong, Nai-Kei [4 ]
Guo, Zhiyong [2 ]
Zou, Kun [2 ]
Xiao, Youli [5 ]
Zhou, Yiqing [1 ,5 ]
机构：
[1] Changshu Inst Technol, Sch Biotechnol & Food Engn, Changshu 215500, Jiangsu, Peoples R China
[2] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China
[3] China Three Gorges Univ, Key Lab Three Gorges Reg Plant Genet & Germplasm, Yichang 443002, Peoples R China
[4] Southern Univ Sci & Technol, Hosp 2, Shenzhen Peoples Hosp 3, Dept Infect Dis, Shenzhen 518112, Peoples R China
[5] Chinese Acad Sci, CAS Ctr Excellence Mol Plant Sci, Inst Plant Physiol & Ecol, Shanghai 200032, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 29期
关键词：
INHIBITION; TARGETS; GLUCOSE;
D O I：
10.1039/c9cc00256a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Natural-product macrolide 10,11-dehydrocurvularin (DCV) was revealed to be a potent irreversible inhibitor of ATP-citrate lyase (ACLY) via classical chemoproteomic profiling, which mechanistically illuminates the anti-cancer mode of action of DCV and its analogues.
引用
收藏
页码：4194 / 4197
页数：4
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