Beyond the Triplet Code: Context Cues Transform Translation

被引：40

作者：

Brar, Gloria A. ^{[1
,2
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[2] Univ Calif San Francisco, Calif Inst Quantitat Biosci QB3, San Francisco, CA 94158 USA

来源：

CELL | 2016年 / 167卷 / 07期

关键词：

RIBOSOME PROFILING REVEALS; NON-AUG CODONS; DYNAMIC N-1-METHYLADENOSINE METHYLOME; MESSENGER-RNA; GENETIC-CODE; IN-VIVO; MAPPING REVEALS; STOP CODON; NUCLEOTIDE RESOLUTION; WIDESPREAD OCCURRENCE;

D O I：

10.1016/j.cell.2016.09.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The elucidation of the genetic code remains among the most influential discoveries in biology. While innumerable studies have validated the general universality of the code and its value in predicting and analyzing protein coding sequences, established and emerging work has also suggested that full genome decryption may benefit from a greater consideration of a codon's neighborhood within an mRNA than has been broadly applied. This Review examines the evidence for context cues in translation, with a focus on several recent studies that reveal broad roles for mRNA context in programming translation start sites, the rate of translation elongation, and stop codon identity.

引用

页码：1681 / 1692

页数：12

共 107 条

[1] Translation readthrough mitigation [J].

Arribere, Joshua A. ;

Cenik, Elif S. ;

Jain, Nimit ;

Hess, Gaelen T. ;

Lee, Cameron H. ;

Bassik, Michael C. ;

Fire, Andrew Z. .

NATURE, 2016, 534 (7609) :719-+

[2] Accounting for biases in riboprofiling data indicates a major role for proline in stalling translation [J].

Artieri, Carlo G. ;

Fraser, Hunter B. .

GENOME RESEARCH, 2014, 24 (12) :2011-2021

[3] Evolution at two levels of gene expression in yeast [J].

Artieri, Carlo G. ;

Fraser, Hunter B. .

GENOME RESEARCH, 2014, 24 (03) :411-421

[4] Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq [J].

Aspden, Julie L. ;

Eyre-Walker, Ying Chen ;

Philips, Rose J. ;

Amin, Unum ;

Mumtaz, Muhammad Ali S. ;

Brocard, Michele ;

Couso, Juan Pablo .

ELIFE, 2014, 3 :1-19

[5] Augmented genetic decoding: global, local and temporal alterations of decoding processes and codon meaning [J].

Baranov, Pavel V. ;

Atkins, John F. ;

Yordanova, Martina M. .

NATURE REVIEWS GENETICS, 2015, 16 (09) :517-529

[6] Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition [J].

Bazzini, Ariel A. ;

del Viso, Florencia ;

Moreno-Mateos, Miguel A. ;

Johnstone, Timothy G. ;

Vejnar, Charles E. ;

Qin, Yidan ;

Yao, Jun ;

Khokha, Mustafa K. ;

Giraldez, Antonio J. .

EMBO JOURNAL, 2016, 35 (19) :2087-2103

[7] Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation [J].

Bazzini, Ariel A. ;

Johnstone, Timothy G. ;

Christiano, Romain ;

Mackowiak, Sebastian D. ;

Obermayer, Benedikt ;

Fleming, Elizabeth S. ;

Vejnar, Charles E. ;

Lee, Miler T. ;

Rajewsky, Nikolaus ;

Walther, Tobias C. ;

Giraldez, Antonio J. .

EMBO JOURNAL, 2014, 33 (09) :981-993

[8] Recode-2: new design, new search tools, and many more genes [J].

Bekaert, Michael ;

Firth, Andrew E. ;

Zhang, Yan ;

Gladyshev, Vadim N. ;

Atkins, John F. ;

Baranov, Pavel V. .

NUCLEIC ACIDS RESEARCH, 2010, 38 :D69-D74

[9] THE INFLUENCE OF CODON CONTEXT ON GENETIC-CODE TRANSLATION [J].

BOSSI, L ;

ROTH, JR .

NATURE, 1980, 286 (5769) :123-127

[10] A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress [J].

Brandman, Onn ;

Stewart-Ornstein, Jacob ;

Wong, Daisy ;

Larson, Adam ;

Williams, Christopher C. ;

Li, Gene-Wei ;

Zhou, Sharleen ;

King, David ;

Shen, Peter S. ;

Weibezahn, Jimena ;

Dunn, Joshua G. ;

Rouskin, Silvi ;

Inada, Toshifumi ;

Frost, Adam ;

Weissman, Jonathan S. .

CELL, 2012, 151 (05) :1042-1054

← 1 2 3 4 5 6 7 8 9 10 →