Parvovirus B19 infection and Diamond-Blackfan anaemia

被引：13
作者：
Heegaard, ED
Hasle, H
Clausen, N
Hornsleth, A
Kerndrup, GB
机构：
[1] ODENSE UNIV HOSP,DEPT PAEDIAT,DK-5000 ODENSE,DENMARK
[2] ODENSE UNIV HOSP,DEPT PATHOL,DK-5000 ODENSE,DENMARK
[3] AARHUS KOMMUNE HOSP,DEPT PAEDIAT,DK-8000 AARHUS,DENMARK
来源：
ACTA PAEDIATRICA | 1996年 / 85卷 / 03期
关键词：
Diamond-Blackfan anaemia; parvovirus B19; polymerase chain reaction;
D O I：
10.1111/j.1651-2227.1996.tb14020.x
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
It is the purpose of the study to report the frequency of parvovirus in children with a diagnosis of Diamond-Blackfan anaemia and to discuss the possible aetiological role of parvovirus in Diamond-Blackfan anaemia. We found parvovirus DNA in 3 of 11 bone marrow smears. Giant pronormoblasts showed low sensitivity (33%) and poor specificity (75%). The presence of giant pronormoblasts was associated with a very high myeloid:erythroid ratio, and may not be specific for parvovirus infection, but a feature of severely suppressed erythropoiesis. The three parvovirus-positive patients were the only children who experienced a remission, and who are free of medication. The seven surviving parvovirus-negative patients are all currently on steroid treatment.
引用
收藏
页码：299 / 302
页数：4
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