Weight loss in adolescents with down syndrome compared to adolescents with other intellectual disabilities enrolled in an 18-month randomized weight management trial

被引:2
作者
Ptomey, Lauren T. [1 ]
Bodde, Amy E. [1 ]
Hastert, Mary [1 ,2 ]
Suire, Kameron B. [1 ]
Helsel, Brian C. [3 ]
Gorczyca, Anna M. [1 ]
Washburn, Richard A. [1 ]
Rice, Annie M. [1 ]
Donnelly, Joseph E. [1 ]
机构
[1] Univ Kansas Med Ctr, Dept Internal Med, Kansas City, KS 66103 USA
[2] Univ Kansas Med Ctr, Dept Dietet & Nutr, Rainbow, KS USA
[3] Univ Kansas Med Ctr, Dept Neurol, Rainbow, KS USA
来源
FRONTIERS IN PEDIATRICS | 2022年 / 10卷
关键词
down syndrome; diet; physical activity; remote delivery; body composition; weight loss; weight maintenance; DEVELOPMENTAL-DISABILITIES; PHYSICAL-ACTIVITY; CHILDREN; OBESITY; OVERWEIGHT; ADULTS; PREVALENCE; RATIONALE; DESIGN; ENERGY;
D O I
10.3389/fped.2022.1022738
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
BackgroundThere is limited information on the efficacy of weight management interventions in adolescents with Down Syndrome (DS) ObjectiveTo compare weight change and intervention compliance between adolescents with DS compared to adolescents with non-DS related intellectual disabilities (ID) who were enrolled in an 18-month weight management trial. MethodsParticipants were adolescents (13-21 years) with mild to moderate ID and overweight or obesity. Participants were randomized in a 1:1:1 allocation to one of 3 intervention arms for an 18-month weight management trial: face-to-face/conventional diet (FTF/CD), remote delivery/conventional diet (RD/CD), or remote delivery/enhanced Stop Light Diet (RD/eSLD). Anthropometrics were assessed at baseline 6, 12, and 18 months by staff blinded to the intervention, and self-monitoring data was collected across the 18-month study. As an unpowered, post-hoc, secondary analysis, two-sample t-tests were used to compare the weight change across 6,12, and 18 mos. and compliance across 18 mos. between adolescents with and without DS randomized to each intervention arm. ResultsAdolescents with ID (n = 110) were randomized to one of three intervention arms: FTF/CD (n = 36, DS = 17, other ID = 19), RD/CD (n = 39, DS = 21, other ID = 18) or RD/eSLD (n = 35, DS = 15, other ID = 20). Body weight at 18 months was obtained from 82%, 76% and 73% of participants with DS and 84%, 83% and 75% of participants with other ID randomized to the FTF/CD, RD/CD, and RD/eSLD arms, respectively Weight change across 18 months was -0.2 +/- 8.8 kg (-0.5%), -0.3 +/- 5.3 kg (-0.7%), and -2.6 +/- 5.0 kg (-4.0%) in adolescents with DS randomized to the FTF/CD, RD/CD and RD/eSLD arms, respectively. There were no significant differences in change in body weight or BMI across 18 months between adolescents with DS or those with other ID in any of the 3 intervention arms (all p > 0.05). Additionally, there were no significant differences in intervention compliance between adolescents with and without DS across 18 mos. (all p > 0.05). ConclusionsAdolescents with DS respond to a multi-component weight management intervention similar to those with others ID
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页数:11
相关论文
共 41 条
[1]  
[Anonymous], 2008, PHYS ACTIVITY GUIDEL
[2]  
[Anonymous], 2010, Report of the Dietary Guidelines Advisory Committee on the Dietary Guidelines for Americans
[3]   A family-based weight loss randomized controlled trial for youth with intellectual disabilities [J].
Bandini, Linda G. ;
Eliasziw, Misha ;
Dittrich, Gretchen A. ;
Curtin, Carol ;
Maslin, Melissa ;
Must, Aviva ;
Boutelle, Kerri N. ;
Fleming, Richard K. .
PEDIATRIC OBESITY, 2021, 16 (11)
[4]   Retrospective Study of Obesity in Children with Down Syndrome [J].
Basil, Janet S. ;
Santoro, Stephanie L. ;
Martin, Lisa J. ;
Healy, Katherine Wusik ;
Chini, Barbara A. ;
Saal, Howard M. .
JOURNAL OF PEDIATRICS, 2016, 173 :143-148
[5]   Overweight and obesity in children and adolescents with Down syndrome-prevalence, determinants, consequences, and interventions: A literature review [J].
Bertapelli, Fabio ;
Pitetti, Ken ;
Agiovlasitis, Stamatis ;
Guerra-Junior, Gil .
RESEARCH IN DEVELOPMENTAL DISABILITIES, 2016, 57 :181-192
[6]   Health Supervision for Children and Adolescents With Down Syndrome [J].
Bull, Marilyn J. ;
Trotter, Tracy ;
Santoro, Stephanie L. ;
Christensen, Celanie ;
Grout, Randall W. .
PEDIATRICS, 2022, 149 (05)
[7]   Down Syndrome [J].
Bull, Marilyn J. .
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (24) :2344-2352
[8]   Parent Support Improves Weight Loss in Adolescents and Young Adults with Down Syndrome [J].
Curtin, Carol ;
Bandini, Linda G. ;
Must, Aviva ;
Gleason, James ;
Lividini, Keith ;
Phillips, Sarah ;
Eliasziw, Misha ;
Maslin, Melissa ;
Fleming, Richard K. .
JOURNAL OF PEDIATRICS, 2013, 163 (05) :1402-+
[9]   Estimation of live birth and population prevalence of Down syndrome in nine US states [J].
de Graaf, Gert ;
Buckley, Frank ;
Dever, Jennifer ;
Skotko, Brian G. .
AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2017, 173 (10) :2710-2719
[10]   Weight management for adolescents with intellectual and developmental disabilities: Rationale and design for an 18 month randomized trial [J].
Donnelly, J. E. ;
Ptomey, L. T. ;
Goetz, J. R. ;
Sullivan, D. K. ;
Gibson, C. A. ;
Greene, J. L. ;
Lee, R. H. ;
Mayo, M. S. ;
Honas, J. J. ;
Washburn, R. A. .
CONTEMPORARY CLINICAL TRIALS, 2016, 51 :88-95