A Neu View of Invasive Lobular Breast Cancer

被引：6

作者：

Bose, Ron ^{[1
,2
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, Div Oncol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA

来源：

CLINICAL CANCER RESEARCH | 2013年 / 19卷 / 13期

关键词：

MUTATIONS; DOMAIN; HER2; AMPLIFICATION; CARCINOMA; ERBB2;

D O I：

10.1158/1078-0432.CCR-13-1031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Genome sequencing of relapsed, invasive lobular breast cancer identified actionable mutations in 86% of the cases. HER2 alterations occur in 27% of the cases, including 4 cases with activating HER2 mutations and 1 with a novel HER2-GRB7 gene fusion. This fusion links the HER2 tyrosine kinase domain to the GRB7 src homology 2 (SH2) domain. (C)2013 AACR.

引用

页码：3331 / 3333

页数：3

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