Deep brain stimulation of the internal capsule enhances human cognitive control and prefrontal cortex function

被引：94
|
作者：
Widge, A. S. [1 ,2 ,3 ,7 ]
Zorowitz, S. [1 ,2 ,8 ]
Basu, I [1 ,2 ]
Paulk, A. C. [4 ,5 ]
Cash, S. S. [4 ,5 ]
Eskandar, E. N. [5 ,6 ,9 ]
Deckersbach, T. [1 ,2 ]
Miller, E. K. [3 ]
Dougherty, D. D. [1 ,2 ]
机构：
[1] Massachusetts Gen Hosp, Dept Psychiat, 149 13th St, Boston, MA 02129 USA
[2] Harvard Med Sch, 149 13th St, Boston, MA 02129 USA
[3] MIT, Picower Inst Learning & Memory, 43 Vassar St, Cambridge, MA 02139 USA
[4] Massachusetts Gen Hosp, Dept Neurol, 55 Fruit St, Boston, MA 02114 USA
[5] Harvard Med Sch, 55 Fruit St, Boston, MA 02114 USA
[6] Massachusetts Gen Hosp, Dept Neurol Surg, 55 Fruit St, Boston, MA 02114 USA
[7] Univ Minnesota, 2001 6th St SE, Minneapolis, MN 55455 USA
[8] Princeton Neurosci Inst, Princeton, NJ 08540 USA
[9] Montefiore Med Ctr, Dept Neurol Surg, Albert Einstein Coll Med, Bronx, NY 10467 USA
来源：
NATURE COMMUNICATIONS | 2019年 / 10卷 / 1期
基金：
美国国家卫生研究院;
关键词：
VENTRAL CAPSULE/VENTRAL STRIATUM; REGRESSION-BASED ESTIMATION; NEURAL OSCILLATIONS; FRONTAL THETA; MECHANISMS; CIRCUIT; MODEL; EEG; MEG; NEUROMODULATION;
D O I：
10.1038/s41467-019-09557-4
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Deep brain stimulation (DBS) is a circuit-oriented treatment for mental disorders. Unfortunately, even well-conducted psychiatric DBS clinical trials have yielded inconsistent symptom relief, in part because DBS' mechanism(s) of action are unclear. One clue to those mechanisms may lie in the efficacy of ventral internal capsule/ventral striatum (VCVS) DBS in both major depression (MDD) and obsessive-compulsive disorder (OCD). MDD and OCD both involve deficits in cognitive control. Cognitive control depends on prefrontal cortex (PFC) regions that project into the VCVS. Here, we show that VCVS DBS' effect is explained in part by enhancement of PFC-driven cognitive control. DBS improves human subjects' performance on a cognitive control task and increases theta (5-8Hz) oscillations in both medial and lateral PFC. The theta increase predicts subjects' clinical outcomes. Our results suggest a possible mechanistic approach to DBS therapy, based on tuning stimulation to optimize these neurophysiologic phenomena.
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页数：11
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