Extraction of Oxytetracycline Hydrochloride in Aqueous Two-phase System of Acetone and Ammonium Sulfate

被引：0
|
作者：
Han, Juan [1 ]
Hu, Shi Ping [2 ]
Wang, Yun [2 ]
Ma, Jing Jing [2 ]
机构：
[1] Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China
[2] Jiangsu Univ, Sch Chem & Chem Engn, Zhenjiang 212013, Peoples R China
来源：
JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN | 2013年 / 35卷 / 01期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
Oxytetracycline hydrochloride; Acetone; Ammonium sulfate; Aqueous two-phase system; Extraction; IONIC LIQUID; WATER; PORPHYRINS; MIXTURE;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Aqueous two-phase system (ATPS) is an efficient implement for separation of various substrates, and extracted by an aqueous two-phase system has been successfully applied in the downstream processing of various biological compounds. In this research, the extraction of oxytetracycline hydrochloride (OTC center dot HCl) was carried out in an aqueous two-phase system containing acetone and ammonium sulfate solution, which partitioned the antibiotic to the upper phase. The effects of some parameters on the extraction efficiency of OTC center dot HCl were studied in detail, including temperature, the volume of acetone, the pH value of ammonium sulfate solution, the concentrations of (NH4)(2)SO4 and OTC center dot HCl. The results showed that the volume of acetone, the pH value of ammonium sulfate solution and the concentration of OTC center dot HCl in feed had significant effects on the extraction efficiency of OTC center dot HCl, but the effects of temperature on the extraction of OTC center dot HCl was not obvious.
引用
收藏
页码：11 / 16
页数：6
相关论文
共 50 条
  • [31] Phase behavior of quaternary aqueous two-phase systems: Influence factors and extraction mechanism study
    Li, Yuliang
    Lu, Xiaojia
    Zhu, Qi
    Huang, Rong
    Hu, Jing
    Yang, Hongbin
    Yao, Yiliang
    FLUID PHASE EQUILIBRIA, 2016, 430 : 101 - 111
  • [32] Ionic liquid-mediated aqueous two-phase system to enhance the partitioning of lignin
    Gogoi, Gayatri
    Hazarika, Swapnali
    CANADIAN JOURNAL OF CHEMICAL ENGINEERING, 2019, 97 (09) : 2527 - 2535
  • [33] Downstream Antibody Purification using Aqueous Two-Phase Extraction
    Mao, Lisong Nathan
    Rogers, Jameson K.
    Westoby, Matthew
    Conley, Lynn
    Pieracci, John
    BIOTECHNOLOGY PROGRESS, 2010, 26 (06) : 1662 - 1670
  • [34] Development of green betaine-based deep eutectic solvent aqueous two-phase system for the extraction of protein
    Li, Na
    Wang, Yuzhi
    Xu, Kaijia
    Huang, Yanhua
    Wen, Qian
    Ding, Xueqin
    TALANTA, 2016, 152 : 23 - 32
  • [35] Ionic liquid-salt aqueous two-phase system, a novel system for the extraction of abused drugs
    Li, SH
    He, CY
    Liu, HW
    Li, KA
    Liu, F
    CHINESE CHEMICAL LETTERS, 2005, 16 (08) : 1074 - 1076
  • [36] Ultrasound assisted extraction in aqueous two-phase system for the integrated extraction and separation of antioxidants from wheat chaff
    Dordevic, Tatjana
    Antov, Mirjana
    SEPARATION AND PURIFICATION TECHNOLOGY, 2017, 182 : 52 - 58
  • [37] Extraction of anionic dyes with ionic liquid-nonionic surfactant aqueous two-phase system
    Zhao, Lihong
    Zhang, Xuehong
    Wang, Zhilong
    SEPARATION SCIENCE AND TECHNOLOGY, 2017, 52 (05) : 804 - 811
  • [38] Purification of recombinant cutinase by extraction in an aqueous two-phase system facilitated by a fatty acid substrate
    Fernandes, S
    Johansson, G
    Hatti-Kaul, R
    BIOTECHNOLOGY AND BIOENGINEERING, 2001, 73 (06) : 465 - 475
  • [39] Extraction in cholinium-based magnetic ionic liquid aqueous two-phase system for the determination of berberine hydrochloride in Rhizoma coptidis
    Nie, Li-rong
    Song, Hang
    Yohannes, Alula
    Liang, Siwei
    Yao, Shun
    RSC ADVANCES, 2018, 8 (44): : 25201 - 25209
  • [40] OPTIMIZATION OF PROPIONIC ACID EXTRACTION BY AQUEOUS TWO-PHASE SYSTEM USING RESPONSE SURFACE METHODOLOGY
    Khayati, Gholam
    CHEMICAL ENGINEERING COMMUNICATIONS, 2013, 200 (05) : 667 - 677
12345