Hippolachnin A, a New Antifungal Polyketide from the South China Sea Sponge Hippospongia lachne

被引：74

作者：

Piao, Shu-Juan ^{[1
]}

Song, Yun-Long ^{[2
]}

Jiao, Wei-Hua ^{[1
]}

Yang, Fan ^{[3
]}

Liu, Xiang-Fang ^{[1
]}

Chen, Wan-Sheng ^{[1
]}

Han, Bing-Nan ^{[3
]}

Lin, Hou-Wen ^{[1
,3
]}

机构：

[1] Second Mil Med Univ, Lab Marine Drugs, Dept Pharm, Changzheng Hosp, Shanghai 200003, Peoples R China

[2] Second Mil Med Univ, Dept Med Chem, Sch Pharm, Shanghai 200433, Peoples R China

[3] Shanghai Jiao Tong Univ, Dept Pharm, Renji Hosp, Affiliated Sch Med, Shanghai 200127, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 14期

基金：

国家高技术研究发展计划(863计划);

关键词：

MARINE SPONGE; SESTERTERPENE SULFATES; STARFISH OOCYTES; CHEMICAL-SHIFTS; OKINAWAN SPONGE; INHIBITORS; ACID;

D O I：

10.1021/ol400933x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hippolachnin A (1), a polyketide possessing an unprecedented carbon skeleton with a four-membered ring, was isolated from the South China Sea sponge Hippospongia lachne. The structure was elucidated using MS and NMR spectroscopic analyses, and the absolute configuration was determined using a calculated ECD method. Hippolachnin A demonstrated potent antifungal activity against three pathogenic fungi, Cryptococcus neoformans, Trichophyton rubrum, and Microsporum gypseum, with a MIC value of 0.41 mu M for each fungus.

引用

页码：3526 / 3529

页数：4

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