Captain GBP1: inflammasomes assemble, pyroptotic endgame

被引：13
作者：
Feng, Shouya [1 ]
Man, Si Ming [1 ]
机构：
[1] Australian Natl Univ, John Curtin Sch Med Res, Dept Immunol & Infect Dis, Canberra, ACT, Australia
来源：
NATURE IMMUNOLOGY | 2020年 / 21卷 / 08期
关键词：
GUANYLATE-BINDING PROTEINS; AIM2; INFLAMMASOME; ACTIVATION; INFECTION;
D O I：
10.1038/s41590-020-0727-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Guanylate-binding proteins (GBPs) promote immune defenses against infectious agents. Two studies reveal that GBP1 directly binds to cytosolic lipopolysaccharide (LPS), bringing caspase-4 to the surface of bacteria to induce pyroptosis.
引用
收藏
页码：829 / 830
页数：2
相关论文
共 13 条
  • [11] Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria
    Santos, Jose Carlos
    Boucher, Dave
    Schneider, Larisa Kapinos
    Demarco, Benjamin
    Dilucca, Marisa
    Shkarina, Kateryna
    Heilig, Rosalie
    Chen, Kaiwen W.
    Lim, Roderick Y. H.
    Broz, Petr
    [J]. NATURE COMMUNICATIONS, 2020, 11 (01)
  • [12] Inflammatory caspases are innate immune receptors for intracellular LPS
    Shi, Jianjin
    Zhao, Yue
    Wang, Yupeng
    Gao, Wenqing
    Ding, Jingjin
    Li, Peng
    Hu, Liyan
    Shao, Feng
    [J]. NATURE, 2014, 514 (7521) : 187 - +
  • [13] Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms
    Wandel, Michal P.
    Kim, Bae-Hoon
    Park, Eui-Soon
    Boyle, Keith B.
    Nayak, Komal
    Lagrange, Brice
    Herod, Adrian
    Henry, Thomas
    Zilbauer, Matthias
    Rohde, John
    MacMicking, John D.
    Randow, Felix
    [J]. NATURE IMMUNOLOGY, 2020, 21 (08) : 880 - +
12