Captain GBP1: inflammasomes assemble, pyroptotic endgame

被引：13

作者：

Feng, Shouya ^{[1
]}

Man, Si Ming ^{[1
]}

机构：

[1] Australian Natl Univ, John Curtin Sch Med Res, Dept Immunol & Infect Dis, Canberra, ACT, Australia

来源：

NATURE IMMUNOLOGY | 2020年 / 21卷 / 08期

关键词：

GUANYLATE-BINDING PROTEINS; AIM2; INFLAMMASOME; ACTIVATION; INFECTION;

D O I：

10.1038/s41590-020-0727-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Guanylate-binding proteins (GBPs) promote immune defenses against infectious agents. Two studies reveal that GBP1 directly binds to cytosolic lipopolysaccharide (LPS), bringing caspase-4 to the surface of bacteria to induce pyroptosis.

引用

页码：829 / 830

页数：2

共 13 条

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