Gallbladder bed resection or hepatectomy of segments 4a and 5 for pT2 gallbladder carcinoma: analysis of Japanese registration cases by the study group for biliary surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery

被引：75

作者：

Horiguchi, Akihiko ^{[1
]}

Miyakawa, Shuichi ^{[1
]}

Ishihara, Shin ^{[1
]}

Miyazaki, Masaru ^{[2
]}

Ohtsuka, Masayuki ^{[2
]}

Shimizu, Hiroaki ^{[2
]}

Sano, Keiji ^{[3
]}

Miura, Fumihiko ^{[3
]}

Ohta, Tetsuo ^{[4
]}

Kayahara, Masato ^{[5
]}

Nagino, Masato ^{[6
]}

Igami, Tsuyoshi ^{[6
]}

Hirano, Satoshi ^{[7
]}

Yamaue, Hiroki ^{[8
]}

Tani, Masaji ^{[8
]}

Yamamoto, Masakazu ^{[9
]}

Ota, Takehiro ^{[9
]}

Shimada, Mitsuo ^{[10
]}

Morine, Yuji ^{[10
]}

Kinoshita, Hisafumi ^{[11
]}

Yasunaga, Masafumi ^{[11
]}

Takada, Tadahiro ^{[3
]}

机构：

[1] Fujita Hlth Univ, Dept Biliary Pancreat Surg, Toyoake, Aichi, Japan

[2] Chiba Univ, Grad Sch Med, Chiba, Japan

[3] Teikyo Univ, Sch Med, Tokyo 173, Japan

[4] Kanazawa Univ, Sch Med, Kanazawa, Ishikawa 920, Japan

[5] Natl Hosp Org, Tokyo, Japan

[6] Nagoya Univ, Grad Sch Med, Nagoya, Aichi 4648601, Japan

[7] Hokkaido Univ, Grad Sch Med, Sapporo, Hokkaido, Japan

[8] Wakayama Med Univ, Sch Med, Wakayama, Japan

[9] Tokyo Womens Med Univ, Tokyo, Japan

[10] Univ Tokushima, Sch Med, Tokushima 770, Japan

[11] Kurume Univ, Sch Med, Kurume, Fukuoka 830, Japan

来源：

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES | 2013年 / 20卷 / 05期

关键词：

Gallbladder carcinoma; Hepatectomy; Hepatic segmentectomy; Gallbladder bed resection; Cholecystectomy; SURGICAL-TREATMENT; RADICAL SURGERY; CANCER; T2; SURVIVAL; STAGE; AREAS; VEIN; CT;

D O I：

10.1007/s00534-012-0584-9

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatectomy of segments 4a and 5 (S4a+5) is the recommended treatment for pT2 gallbladder cancer. However, gallbladder bed resection is also occasionally used. Using nationwide data from the Japanese Biliary Tract Cancer Registry and a questionnaire survey, we retrospectively compared these 2 methods of treatment. The study involved 85 patients with pT2, pN0 gallbladder cancer (55 treated with gallbladder bed resection, and 30, with S4a+5 hepatectomy). The prognosis and mode of tumor recurrence following treatment were analyzed retrospectively, with overall survival as the endpoint. The 5-year survival rate did not differ significantly between the 2 groups. Univariate analysis showed that bile duct resection and perineural tumor invasion were significant prognostic factors, but the extent of hepatectomy, location of the major intramural tumor, regional lymph node excision, and histological type were not. Multivariate analysis identified perineural tumor invasion as a significant prognostic factor. Recurrence occurred most frequently in both lobes than S4a+5 of the liver following gallbladder bed resection. In the present study of cases of Japanese Biliary Tract Cancer Registry, it was not possible to conclude that S4a+5 hepatectomy was superior to gallbladder bed resection.

引用

页码：518 / 524

页数：7

共 23 条

[1] Hepatic resection in 485 R0 pT2 and pT3 cases of advanced carcinoma of the gallbladder: results of a Japanese Society of Biliary Surgery survey-a multicenter study [J].