共 42 条
The Association of Retinol-Binding Protein 4 With Metabolic Syndrome and Obesity in Adolescents: The Effects of Gender and Sex Hormones
被引:21
作者:

Lin, Chin-Jung
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机构: Triserv Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei, Taiwan

Chu, Nain Feng
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h-index: 0
机构:
Natl Def Med Ctr, Taipei, Taiwan Triserv Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei, Taiwan

Hung, Yi-Jen
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机构: Triserv Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei, Taiwan

Chang, Jin-Biou
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Def Med Ctr, Taipei, Taiwan Triserv Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei, Taiwan

He, Chih-Tsueng
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机构: Triserv Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei, Taiwan

Hsiao, Fone-Ching
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h-index: 0
机构: Triserv Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei, Taiwan

Hsieh, Chang-Hsun
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h-index: 0
机构:
Triserv Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei, Taiwan Triserv Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei, Taiwan
机构:
[1] Triserv Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei, Taiwan
[2] Natl Def Med Ctr, Taipei, Taiwan
关键词:
retinol-binding protein 4;
insulin resistance;
obesity;
adolescence;
metabolic syndrome;
HOMEOSTASIS MODEL ASSESSMENT;
SENSITIVITY CHECK INDEX;
INSULIN-RESISTANCE;
SERUM RETINOL-BINDING-PROTEIN-4;
ADIPOSE-TISSUE;
SCHOOL-CHILDREN;
OVERWEIGHT;
EXPRESSION;
FAT;
DIMORPHISM;
D O I:
10.1177/0009922812459948
中图分类号:
R72 [儿科学];
学科分类号:
100202 ;
摘要:
Objectives. Retinol-binding protein 4 (RBP4) has a role in the development of insulin resistance (IR), type 2 diabetes, obesity, and metabolic syndrome among adults. However, data among adolescents are limited, and the effects of gender and sex hormones on RBP4 are not well defined. Materials/Methods. A total of 1082 adolescents were enrolled and categorized based on their body mass index. Blood samples were collected, and biochemical characteristics, sex hormones, RBP4 concentrations, and IR were determined. Results. Testosterone and estradiol were not directly correlated with RBP4 concentrations in both genders. Multivariate regression analysis revealed that fasting plasma glucose (FPG), triglyceride (TG), and testosterone levels were independently associated with RBP4 concentrations in boys; also, there was a trend of increasing RBP4 levels with the severity of obesity. Conclusion. Plasma RBP4 concentrations correlated with obesity and cardiovascular risk factors, predominantly evident in boys. Testosterone, FPG, and TG levels were independent predictors of RBP4 concentrations.
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页码:16 / 23
页数:8
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