Growth factors and chondrogenic differentiation of mesenchymal stem cells

被引：106
作者：
Danisovic, L. [1 ,2 ]
Varga, I. [2 ,3 ]
Polak, S. [3 ]
机构：
[1] Comenius Univ, Inst Med Biol Genet & Clin Genet, Fac Med, Bratislava 81108, Slovakia
[2] St Elizabeth Univ Hlth & Social Sci, Inst Lab Med, Bratislava 81000, Slovakia
[3] Comenius Univ, Fac Med, Inst Histol & Embryol, Bratislava 81108, Slovakia
来源：
TISSUE & CELL | 2012年 / 44卷 / 02期
关键词：
Mesenchymal stem cells; Growth factors; Chondrogenic differentiation; BONE MORPHOGENETIC PROTEIN-2; ARTICULAR-CARTILAGE; ADIPOSE-TISSUE; FACTOR-BETA; IN-VITRO; MARROW; OSTEOARTHRITIS; REPAIR; IGF-1; CHONDROCYTES;
D O I：
10.1016/j.tice.2011.11.005
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
The main purpose of the article is to review recent knowledge about growth factors and their effect on the chondrogenic differentiation of mesenchymal stem cells under in vitro conditions. Damaged or lost articular cartilage leads to progressive debilitation, which have major impact on the life quality of the affected individuals of both sexes in all age groups. Mature hyaline cartilage has a very low self-repair potential due to intrinsic properties - lack of innervation and vascular supply. Another limiting factor is low mitotic potential of chondrocytes. Small defects are healed by migration of chondrocytes, while large ones are healed by formation of inferior fibrocartilage. However, in many cases osteoarthritis develops. Recently, cellular therapy combining mesenchymal stem cells and proper differentiation factors seems to be promising tool for hyaline cartilage defects healing. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：69 / 73
页数：5
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