The immune system's involvement in obesity-driven type 2 diabetes

被引：134
|
作者：
Shu, Chengyi Jenny [1 ]
Benoist, Christophe [1 ]
Mathis, Diane [1 ]
机构：
[1] Harvard Univ, Div Immunol, Dept Microbiol & Immunobiol, Sch Med, Boston, MA 02115 USA
来源：
SEMINARS IN IMMUNOLOGY | 2012年 / 24卷 / 06期
关键词：
Obesity; Type; 2; diabetes; Inflammation; Adipose tissue; Insulin resistance; DIET-INDUCED OBESITY; REGULATORY T-CELLS; ADIPOSE-TISSUE MACROPHAGES; INDUCED INSULIN-RESISTANCE; NECROSIS-FACTOR-ALPHA; FREE FATTY-ACIDS; B-CELLS; ALTERNATIVE ACTIVATION; NLRP3; INFLAMMASOME; UNIQUE POPULATION;
D O I：
10.1016/j.smim.2012.12.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Type 2 diabetes is now a worldwide epidemic, strongly correlated with an elevated incidence of obesity. Obesity-associated adipose tissue inflammation is a major cause of the decreased insulin sensitivity seen in type 2 diabetes. Recent studies have shed light on the cross-talk between the immune system and organismal metabolism. This review discusses the connection between inflammation in adipose tissue and systemic insulin resistance, focusing on the roles of innate and adaptive immune cell subsets in the pathogenesis of this metabolic disease. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：436 / 442
页数：7
相关论文
共 50 条
  • [41] Role of Gut Microbiota in Obesity, Type 2 Diabetes and Alzheimer's Disease
    Naseer, Muhammad I.
    Bibi, Fehmida
    Alqahtani, Mohammed H.
    Chaudhary, Adeel G.
    Azhar, Esam I.
    Kamal, Mohammad A.
    Yasir, Muhammad
    CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2014, 13 (02) : 305 - 311
  • [42] The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity
    Tai, Ningwen
    Wong, F. Susan
    Wen, Li
    REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 2015, 16 (01) : 55 - 65
  • [43] Epigenetics: spotlight on type 2 diabetes and obesity
    Desiderio, A.
    Spinelli, R.
    Ciccarelli, M.
    Nigro, C.
    Miele, C.
    Beguinot, F.
    Raciti, G. A.
    JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2016, 39 (10) : 1095 - 1103
  • [44] Fight for survival: type 2 diabetes and obesity
    Manuel Fernandez-Real, Jose
    AVANCES EN DIABETOLOGIA, 2012, 28 (02): : 55 - 58
  • [45] Dysfunction of human subcutaneous fat arterioles in obesity alone or obesity associated with Type 2 diabetes
    Georgescu, Adriana
    Popov, Doina
    Constantin, Anamaria
    Nemecz, Miruna
    Alexandru, Nicoleta
    Cochior, Daniel
    Tudor, Aura
    CLINICAL SCIENCE, 2011, 120 (9-10) : 463 - 472
  • [46] Chemerin: a potential endocrine link between obesity and type 2 diabetes
    Roman, Alexandra A.
    Parlee, Sebastian D.
    Sinal, Christopher J.
    ENDOCRINE, 2012, 42 (02) : 243 - 251
  • [47] Sleep influences on obesity, insulin resistance, and risk of type 2 diabetes
    Reutrakul, Sirimon
    Van Cauter, Eve
    METABOLISM-CLINICAL AND EXPERIMENTAL, 2018, 84 : 56 - 66
  • [48] Glutamine Metabolism in Macrophages: A Novel Target for Obesity/Type 2 Diabetes
    Ren, Wenkai
    Xia, Yaoyao
    Chen, Siyuan
    Wu, Guoyao
    Bazer, Fuller W.
    Zhou, Beiyan
    Tan, Bie
    Zhu, Guoqiang
    Deng, Jinping
    Yin, Yulong
    ADVANCES IN NUTRITION, 2019, 10 (02) : 321 - 330
  • [49] Ghrelin function in human obesity and type 2 diabetes: a concise review
    Churm, R.
    Davies, J. S.
    Stephens, J. W.
    Prior, S. L.
    OBESITY REVIEWS, 2017, 18 (02) : 140 - 148
  • [50] Treatment with a Catalytic Superoxide Dismutase (SOD) Mimetic Improves Liver Steatosis, Insulin Sensitivity, and Inflammation in Obesity-Induced Type 2 Diabetes
    Coudriet, Gina M.
    Delmastro-Greenwood, Meghan M.
    Previte, Dana M.
    Marre, Meghan L.
    O'Connor, Erin C.
    Novak, Elizabeth A.
    Vincent, Garret
    Mollen, Kevin P.
    Lee, Sojin
    Dong, H. Henry
    Piganelli, Jon D.
    ANTIOXIDANTS, 2017, 6 (04)
12345